DegronMD

Uniprot ID: A1L170

Source protein: Uncharacterized protein C1orf226

Source gene: C1orf226

Class: DEG_COP1_1

Location: 194:202

E3 ligase: COP1

DEGRON score: 0.9621

ASA_SCORE: 60.4222

COIL: 0.6393

CONS_SCORE: 0.4993

DSS_SCORE: 0.5655

HELIX: 0.1484

FCONS_SCORE: 1.5375

RIG_SCORE: 0.7008

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q185H	TCGA-73-4670	LUAD	TCGA	EVSLSVPDL	DEG_COP1_1	0.0833
p.L188I	TCGA-AA-A00N	COAD	TCGA	EVSLSVPDL	DEG_COP1_1	0.2778
p.S189I	TCGA-B5-A1MX	UCEC	TCGA	EVSLSVPDL	DEG_COP1_1	0.1944
p.G194R	TCGA-DA-A3F5	SKCM	TCGA	EVSLSVPDL	DEG_COP1_1	0.7568
p.A206T	TCGA-E6-A1LX	UCEC	TCGA	EVSLSVPDL	DEG_COP1_1	0.2222
p.S198L	TCGA-EE-A3AC	SKCM	TCGA	EVSLSVPDL	DEG_COP1_1	0.7667
p.E184K	DO218176	BRCA	ICGC	EVSLSVPDL	DEG_COP1_1	0.0556
p.K205E	DO229013	COCA	ICGC	EVSLSVPDL	DEG_COP1_1	0.3611
p.D206Y	DO52502	EOPC	ICGC	EVSLSVPDL	DEG_COP1_1	0.2222
p.S196F	DO222527	MELA	ICGC	EVSLSVPDL	DEG_COP1_1	0.7982
p.E210K	DO37966	SKCM	ICGC	EVSLSVPDL	DEG_COP1_1	0.1111
p.V195L	DO41494	UCEC	ICGC	EVSLSVPDL	DEG_COP1_1	0.5654
p.S184L	SIDM00499	Prostate Carcinoma	GDSC	EVSLSVPDL	DEG_COP1_1	0.0556
p.P199L	SIDM00679	Cervical Carcinoma	GDSC	EVSLSVPDL	DEG_COP1_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L170	Uncharacterized protein C1orf226	DEG_COP1_1	194:202	EVSLSVPDL	COP1	0.9621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons