DegronMD

Uniprot ID: Q6RI45

Source protein: Bromodomain and WD repeat-containing protein 3

Source gene: BRWD3

Class: LIG_APCC_ABBAyCdc20_2

Location: 1755:1761

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9258

ASA_SCORE: 107.3143

COIL: 0.7661

CONS_SCORE: 0.2886

DSS_SCORE: 0.4956

HELIX: 0.0257

FCONS_SCORE: 0.9498

RIG_SCORE: 0.7699

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1752H	TCGA-49-6761	LUAD	TCGA	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.25
p.Q1752H	DO24566	LUAD	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.25
p.F1768V	TCGA-AA-3984	COAD	TCGA	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.1389
p.F1768V	DO9002	COAD	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.1389
p.R1755M	TCGA-DU-6392	LGG	TCGA	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.8632
p.R1755M	DO22237	LGG	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.8632
p.T1771A	DO227802	COCA	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.0556
p.D1766H	DO223037	ESCA	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.1944
p.R1746Q	DO233624	GACA	ICGC	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1746Q	SIDM02056	Pancreatic Carcinoma	GDSC	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.0833
p.V1769M	SIDM01090	Colorectal Carcinoma	GDSC	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.1111
p.V1769M	ACH-000943	Colon/Colorectal Cancer	CCLE	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.1111
p.V1769M	RKO	large_intestine	COSMIC	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1754W	ACH-000586	Lung Cancer	CCLE	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.3056
p.R1754W	NCI-H1876	lung	COSMIC	RTVLYND	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6RI45	Bromodomain and WD repeat-containing protein 3	LIG_APCC_ABBAyCdc20_2	1755:1761	RTVLYND	APC,CDC20,FZR1	0.9258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons