DegronMD

Uniprot ID: Q9UKG1

Source protein: DCC-interacting protein 13-alpha

Source gene: APPL1

Class: DEG_SCF_FBW7_1

Location: 398:403

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 71.9167

COIL: 0.7807

CONS_SCORE: 0.5212

DSS_SCORE: 0.6374

HELIX: 0.1868

FCONS_SCORE: 1.1199

RIG_SCORE: 0.6389

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R412Q	TCGA-A5-A1OF	UCEC	TCGA	VTPSPS	DEG_SCF_FBW7_1	0.0833
p.R412Q	DO42568	UCEC	ICGC	VTPSPS	DEG_SCF_FBW7_1	0.0833
p.R412Q	SIDM00530	Esophageal Carcinoma	GDSC	VTPSPS	DEG_SCF_FBW7_1	0.0833
p.R412Q	SIDM00821	Kidney Carcinoma	GDSC	VTPSPS	DEG_SCF_FBW7_1	0.0833
p.R412Q	ACH-001544	Esophageal Cancer	CCLE	VTPSPS	DEG_SCF_FBW7_1	0.0833
p.R412Q	KYAE-1	oesophagus	COSMIC	VTPSPS	DEG_SCF_FBW7_1	0.0833
p.R389Q	TCGA-AX-A1C5	UCEC	TCGA	VTPSPS	DEG_SCF_FBW7_1	0.0833
p.R389Q	DO229051	LICA	ICGC	VTPSPS	DEG_SCF_FBW7_1	0.0833
p.R389Q	DO41422	UCEC	ICGC	VTPSPS	DEG_SCF_FBW7_1	0.0833
p.E409K	TCGA-AX-A2HC	UCEC	TCGA	VTPSPS	DEG_SCF_FBW7_1	0.1667
p.E409K	DO233898	GACA	ICGC	VTPSPS	DEG_SCF_FBW7_1	0.1667
p.E409K	DO41572	UCEC	ICGC	VTPSPS	DEG_SCF_FBW7_1	0.1667
p.H408Y	TCGA-E6-A1LX	UCEC	TCGA	VTPSPS	DEG_SCF_FBW7_1	0.1944
p.H408Y	DO41020	UCEC	ICGC	VTPSPS	DEG_SCF_FBW7_1	0.1944
p.V398I	TCGA-FD-A43N	BLCA	TCGA	VTPSPS	DEG_SCF_FBW7_1	0.5965
p.V398I	DO502	BLCA	ICGC	VTPSPS	DEG_SCF_FBW7_1	0.5965
p.H408Q	SIDM00254	Neuroblastoma	GDSC	VTPSPS	DEG_SCF_FBW7_1	0.1944
p.H408Q	ACH-002283	Neuroblastoma	CCLE	VTPSPS	DEG_SCF_FBW7_1	0.1944
p.H408Q	NB5	autonomic_ganglia	COSMIC	VTPSPS	DEG_SCF_FBW7_1	0.1944
p.V398G	SIDM01012	Other Blood Cancers	GDSC	VTPSPS	DEG_SCF_FBW7_1	0.7532
p.V398G	ACH-000346	Leukemia	CCLE	VTPSPS	DEG_SCF_FBW7_1	0.7532
p.V398G	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSPS	DEG_SCF_FBW7_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SCF_FBW7_1	398:403	VTPSPS	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons