DegronMD

Uniprot ID: Q9UKG1

Source protein: DCC-interacting protein 13-alpha

Source gene: APPL1

Class: DEG_COP1_1

Location: 258:266

E3 ligase: COP1

DEGRON score: 0.9843

ASA_SCORE: 90.7556

COIL: 0.914

CONS_SCORE: 0.4376

DSS_SCORE: 0.5363

HELIX: 0.0404

FCONS_SCORE: 0.9563

RIG_SCORE: 0.7213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P272H	TCGA-A5-A0G2	UCEC	TCGA	SDPLYVPDP	DEG_COP1_1	0.1667
p.P272H	DO41235	UCEC	ICGC	SDPLYVPDP	DEG_COP1_1	0.1667
p.R275Q	TCGA-AA-3510	COAD	TCGA	SDPLYVPDP	DEG_COP1_1	0.0833
p.R275Q	TCGA-EO-A3B0	UCEC	TCGA	SDPLYVPDP	DEG_COP1_1	0.0833
p.R275Q	DO7783	COAD	ICGC	SDPLYVPDP	DEG_COP1_1	0.0833
p.R275Q	DO228935	COCA	ICGC	SDPLYVPDP	DEG_COP1_1	0.0833
p.R275Q	DO219773	UCEC	ICGC	SDPLYVPDP	DEG_COP1_1	0.0833
p.L254F	TCGA-AP-A0LM	UCEC	TCGA	SDPLYVPDP	DEG_COP1_1	0.2222
p.L254F	DO43306	UCEC	ICGC	SDPLYVPDP	DEG_COP1_1	0.2222
p.N274D	TCGA-EY-A2OM	UCEC	TCGA	SDPLYVPDP	DEG_COP1_1	0.1111
p.N274D	DO43025	UCEC	ICGC	SDPLYVPDP	DEG_COP1_1	0.1111
p.P260L	TCGA-FS-A1ZC	SKCM	TCGA	SDPLYVPDP	DEG_COP1_1	0.6471
p.P260L	DO37487	SKCM	ICGC	SDPLYVPDP	DEG_COP1_1	0.6471
p.D259Y	TCGA-XR-A8TF	LIHC	TCGA	SDPLYVPDP	DEG_COP1_1	0.7325
p.D259Y	DO223923	LIHC	ICGC	SDPLYVPDP	DEG_COP1_1	0.7325
p.S258N	DO10324	COAD	ICGC	SDPLYVPDP	DEG_COP1_1	0.818
p.D267N	DO233800	GACA	ICGC	SDPLYVPDP	DEG_COP1_1	0.3056
p.D267Y	DO229009	LICA	ICGC	SDPLYVPDP	DEG_COP1_1	0.3056
p.I251V	SIDM00103	Mesothelioma	GDSC	SDPLYVPDP	DEG_COP1_1	0.1389
p.I251V	ACH-002124	Lung Cancer	CCLE	SDPLYVPDP	DEG_COP1_1	0.1389
p.I251V	H2373	pleura	COSMIC	SDPLYVPDP	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKG1	DCC-interacting protein 13-alpha	DEG_COP1_1	258:266	SDPLYVPDP	COP1	0.9843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons