DegronMD - Q05209(PTPN12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S625L	TCGA-52-7812	LUSC	TCGA	AATST	DEG_SPOP_SBC_1	633:637	Mutation rewiring degron network	0.1111
p.N504D	TCGA-CV-6951	HNSC	TCGA	VSVTPPEE	DEG_SCF_FBW7_2	506:513	Mutation rewiring degron network	0.2778
p.P511Q	TCGA-EE-A3AD	SKCM	TCGA	VSVTPPEE	DEG_SCF_FBW7_2	506:513	Mutation altering degron motif	0.5924
p.T642A	TCGA-EQ-5647	STAD	TCGA	AATST	DEG_SPOP_SBC_1	633:637	Mutation rewiring degron network	0.1944
p.Q575K	TCGA-GU-A764	BLCA	TCGA	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.2778
p.R577Q	DO476	BLCA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.2222
p.R577Q	DO46825	RECA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.2222
p.R577Q	DO41235	UCEC	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.2222
p.A558V	DO1749	BRCA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.1111
p.V556L	DO44088	COAD	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.0556
p.R577L	DO9876	COAD	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.2222
p.R635Q	DO9876	COAD	ICGC	AATST	DEG_SPOP_SBC_1	633:637	Mutation altering degron motif	0.7329
p.R635Q	DO47769	STAD	ICGC	AATST	DEG_SPOP_SBC_1	633:637	Mutation altering degron motif	0.7329
p.D629A	DO222798	COCA	ICGC	AATST	DEG_SPOP_SBC_1	633:637	Mutation rewiring degron network	0.2222
p.S567T	DO228124	EOPC	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation altering degron motif	0.7116
p.M518V	DO12898	GBM	ICGC	VSVTPPEE	DEG_SCF_FBW7_2	506:513	Mutation rewiring degron network	0.1944
p.W569L	DO229024	LICA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation altering degron motif	0.7015
p.W569L	DO37679	SKCM	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation altering degron motif	0.7015
p.A499S	DO229031	LICA	ICGC	VSVTPPEE	DEG_SCF_FBW7_2	506:513	Mutation rewiring degron network	0.1389
p.S570T	DO23663	LUAD	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation altering degron motif	0.7116
p.A499V	DO220857	MELA	ICGC	VSVTPPEE	DEG_SCF_FBW7_2	506:513	Mutation rewiring degron network	0.1389
p.E568Q	DO27879	ORCA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation altering degron motif	0.6744
p.P624S	DO37782	SKCM	ICGC	AATST	DEG_SPOP_SBC_1	633:637	Mutation rewiring degron network	0.0833
p.P564H	DO47623	SKCM	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.2778
p.P624L	DO51276	SKCM	ICGC	AATST	DEG_SPOP_SBC_1	633:637	Mutation rewiring degron network	0.0833
p.T512A	DO38807	STAD	ICGC	VSVTPPEE	DEG_SCF_FBW7_2	506:513	Mutation altering degron motif	0.7139
p.Q580K	DO229268	THCA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.1389
p.K582R	DO219773	UCEC	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.0833
p.N623H	DO43202	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	633:637	Mutation rewiring degron network	0.0556
p.Q575H	DO41361	UCEC	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.2778
p.N559S	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.1389
p.N559S	SIDM00736	Non-Cancerous	GDSC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.1389
p.N559S	ACH-000886	Lung Cancer	CCLE	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.1389
p.N559S	ACH-002366	Non-Cancerous	CCLE	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.1389
p.T635I	SIDM00011	Melanoma	GDSC	AATST	DEG_SPOP_SBC_1	633:637	Mutation altering degron motif	0.7078
p.T635I	ACH-000477	Skin Cancer	CCLE	AATST	DEG_SPOP_SBC_1	633:637	Mutation altering degron motif	0.7078
p.E571K	DJM-1	skin	COSMIC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation altering degron motif	0.7022
p.E560K	DJM-1	skin	COSMIC	VSLTPSPT	DEG_SCF_FBW7_1	566:573	Mutation rewiring degron network	0.1667

Kaplan plot for PTPN12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPN12

UniProt ID: Q05209

Entrez ID: 5782

Protein name: Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPN12 in