DegronMD

Uniprot ID: Q05209

Source protein: Tyrosine-protein phosphatase non-receptor type 12

Source gene: PTPN12

Class: DEG_SCF_FBW7_2

Location: 506:513

E3 ligase: FBXW7

DEGRON score: 0.9801

ASA_SCORE: 93.2375

COIL: 0.9399

CONS_SCORE: 0.502

DSS_SCORE: 0.7121

HELIX: 0.0328

FCONS_SCORE: 1.0103

RIG_SCORE: 0.6257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N504D	TCGA-CV-6951	HNSC	TCGA	VSVTPPEE	DEG_SCF_FBW7_2	0.2778
p.P511Q	TCGA-EE-A3AD	SKCM	TCGA	VSVTPPEE	DEG_SCF_FBW7_2	0.5924
p.M518V	DO12898	GBM	ICGC	VSVTPPEE	DEG_SCF_FBW7_2	0.1944
p.A499S	DO229031	LICA	ICGC	VSVTPPEE	DEG_SCF_FBW7_2	0.1389
p.A499V	DO220857	MELA	ICGC	VSVTPPEE	DEG_SCF_FBW7_2	0.1389
p.T512A	DO38807	STAD	ICGC	VSVTPPEE	DEG_SCF_FBW7_2	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q05209	Tyrosine-protein phosphatase non-receptor type 12	DEG_SCF_FBW7_2	506:513	VSVTPPEE	FBXW7	0.9801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons