DegronMD

Uniprot ID: Q05209

Source protein: Tyrosine-protein phosphatase non-receptor type 12

Source gene: PTPN12

Class: DEG_SCF_FBW7_1

Location: 566:573

E3 ligase: FBXW7

DEGRON score: 0.9807

ASA_SCORE: 92.75

COIL: 0.9365

CONS_SCORE: 0.5125

DSS_SCORE: 0.5964

HELIX: 0.0149

FCONS_SCORE: 1.0461

RIG_SCORE: 0.6508

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q575K	TCGA-GU-A764	BLCA	TCGA	VSLTPSPT	DEG_SCF_FBW7_1	0.2778
p.R577Q	DO476	BLCA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.2222
p.R577Q	DO46825	RECA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.2222
p.R577Q	DO41235	UCEC	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.2222
p.A558V	DO1749	BRCA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.1111
p.V556L	DO44088	COAD	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.0556
p.R577L	DO9876	COAD	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.2222
p.S567T	DO228124	EOPC	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.7116
p.W569L	DO229024	LICA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.7015
p.W569L	DO37679	SKCM	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.7015
p.S570T	DO23663	LUAD	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.7116
p.E568Q	DO27879	ORCA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.6744
p.P564H	DO47623	SKCM	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.2778
p.Q580K	DO229268	THCA	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.1389
p.K582R	DO219773	UCEC	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.0833
p.Q575H	DO41361	UCEC	ICGC	VSLTPSPT	DEG_SCF_FBW7_1	0.2778
p.N559S	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	VSLTPSPT	DEG_SCF_FBW7_1	0.1389
p.N559S	SIDM00736	Non-Cancerous	GDSC	VSLTPSPT	DEG_SCF_FBW7_1	0.1389
p.N559S	ACH-000886	Lung Cancer	CCLE	VSLTPSPT	DEG_SCF_FBW7_1	0.1389
p.N559S	ACH-002366	Non-Cancerous	CCLE	VSLTPSPT	DEG_SCF_FBW7_1	0.1389
p.E571K	DJM-1	skin	COSMIC	VSLTPSPT	DEG_SCF_FBW7_1	0.7022
p.E560K	DJM-1	skin	COSMIC	VSLTPSPT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q05209	Tyrosine-protein phosphatase non-receptor type 12	DEG_SCF_FBW7_1	566:573	VSLTPSPT	FBXW7	0.9807	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons