DegronMD - Q08945(SSRP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S695N	TCGA-19-5956	GBM	TCGA	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation altering degron motif	0.5958
p.S695N	DO13863	GBM	ICGC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation altering degron motif	0.5958
p.K461N	TCGA-19-5956	GBM	TCGA	SDDSGE	DEG_Kelch_Keap1_1	471:476	Mutation substituting flanking lysine	0.1667
p.K461N	DO13863	GBM	ICGC	SDDSGE	DEG_Kelch_Keap1_1	471:476	Mutation substituting flanking lysine	0.1667
p.D513N	TCGA-2W-A8YY	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.1111
p.D513N	DO223732	CESC	ICGC	ASSSS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.1111
p.N483K	TCGA-42-2582	OV	TCGA	SDDSGE	DEG_Kelch_Keap1_1	471:476	Mutation rewiring degron network	0.1389
p.N483K	TCGA-42-2582	OV	TCGA	DSGEET	DEG_SCF_TRCP1_1	473:478	Mutation rewiring degron network	0.1944
p.N483K	TCGA-56-7823	LUSC	TCGA	SDDSGE	DEG_Kelch_Keap1_1	471:476	Mutation rewiring degron network	0.1389
p.N483K	TCGA-56-7823	LUSC	TCGA	DSGEET	DEG_SCF_TRCP1_1	473:478	Mutation rewiring degron network	0.1944
p.N483K	DO223721	LUSC	ICGC	SDDSGE	DEG_Kelch_Keap1_1	471:476	Mutation rewiring degron network	0.1389
p.N483K	DO223721	LUSC	ICGC	DSGEET	DEG_SCF_TRCP1_1	473:478	Mutation rewiring degron network	0.1944
p.N483K	DO28721	OV	ICGC	SDDSGE	DEG_Kelch_Keap1_1	471:476	Mutation rewiring degron network	0.1389
p.N483K	DO28721	OV	ICGC	DSGEET	DEG_SCF_TRCP1_1	473:478	Mutation rewiring degron network	0.1944
p.D708N	TCGA-AP-A0LM	UCEC	TCGA	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation rewiring degron network	0.1111
p.D708N	DO222462	ESCA	ICGC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation rewiring degron network	0.1111
p.D708N	DO43306	UCEC	ICGC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation rewiring degron network	0.1111
p.A704V	TCGA-AX-A06F	UCEC	TCGA	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation rewiring degron network	0.2222
p.A704V	DO41752	UCEC	ICGC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation rewiring degron network	0.2222
p.S699G	TCGA-B5-A3FA	UCEC	TCGA	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation altering degron motif	0.6993
p.S699G	DO52402	UCEC	ICGC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation altering degron motif	0.6993
p.E701Q	TCGA-E9-A1NA	BRCA	TCGA	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation rewiring degron network	0.3056
p.E701Q	DO1522	BRCA	ICGC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation rewiring degron network	0.3056
p.E487K	TCGA-EE-A2GO	SKCM	TCGA	DSGEET	DEG_SCF_TRCP1_1	473:478	Mutation rewiring degron network	0.0833
p.E487K	DO37823	SKCM	ICGC	DSGEET	DEG_SCF_TRCP1_1	473:478	Mutation rewiring degron network	0.0833
p.A499T	TCGA-EO-A22U	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.2778
p.A499T	DO43755	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.2778
p.E514K	TCGA-S5-A6DX	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.0833
p.E514K	DO51903	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.0833
p.E480K	DO225253	BRCA	ICGC	SDDSGE	DEG_Kelch_Keap1_1	471:476	Mutation rewiring degron network	0.2222
p.E480K	DO225253	BRCA	ICGC	DSGEET	DEG_SCF_TRCP1_1	473:478	Mutation rewiring degron network	0.2778
p.K515N	DO222884	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	501:505	Mutation substituting flanking lysine	0.1667
p.S707Y	DO229018	LICA	ICGC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation rewiring degron network	0.1389
p.P697T	DO229027	LICA	ICGC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation altering degron motif	0.7031
p.P697H	DO229006	LICA	ICGC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation altering degron motif	0.7694
p.E692Q	SIDM00620	Glioblastoma	GDSC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation rewiring degron network	0.3056
p.E692Q	D-336MG	central nervous system	COSMIC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation rewiring degron network	0.3056
p.R463W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SDDSGE	DEG_Kelch_Keap1_1	471:476	Mutation rewiring degron network	0.1111
p.R463W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGEET	DEG_SCF_TRCP1_1	473:478	Mutation rewiring degron network	0.0556
p.R463W	ACH-002256	Leukemia	CCLE	SDDSGE	DEG_Kelch_Keap1_1	471:476	Mutation rewiring degron network	0.1111
p.R463W	ACH-002256	Leukemia	CCLE	DSGEET	DEG_SCF_TRCP1_1	473:478	Mutation rewiring degron network	0.0556
p.R463W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SDDSGE	DEG_Kelch_Keap1_1	471:476	Mutation rewiring degron network	0.1111
p.R463W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGEET	DEG_SCF_TRCP1_1	473:478	Mutation rewiring degron network	0.0556
p.T696I	SIDM00272	Breast Carcinoma	GDSC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation altering degron motif	0.8189
p.T696I	ACH-000910	Breast Cancer	CCLE	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation altering degron motif	0.8189
p.T696I	MDA-MB-453	breast	COSMIC	LASTPPSS	DEG_SCF_FBW7_1	693:700	Mutation altering degron motif	0.8189
p.R463Q	ACH-001719	Ovarian Cancer	CCLE	SDDSGE	DEG_Kelch_Keap1_1	471:476	Mutation rewiring degron network	0.1111
p.R463Q	ACH-001719	Ovarian Cancer	CCLE	DSGEET	DEG_SCF_TRCP1_1	473:478	Mutation rewiring degron network	0.0556

Kaplan plot for SSRP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SSRP1

UniProt ID: Q08945

Entrez ID: 6749

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SSRP1 in