DegronMD

Uniprot ID: Q08945

Source protein: FACT complex subunit SSRP1

Source gene: SSRP1

Class: DEG_SCF_TRCP1_1

Location: 473:478

E3 ligase: BTRC

DEGRON score: 0.9947

ASA_SCORE: 73.8667

COIL: 0.8032

CONS_SCORE: 0.5337

DSS_SCORE: 0.8973

HELIX: 0.1343

FCONS_SCORE: 1.401

RIG_SCORE: 0.5602

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N483K	TCGA-42-2582	OV	TCGA	DSGEET	DEG_SCF_TRCP1_1	0.1944
p.N483K	TCGA-56-7823	LUSC	TCGA	DSGEET	DEG_SCF_TRCP1_1	0.1944
p.N483K	DO223721	LUSC	ICGC	DSGEET	DEG_SCF_TRCP1_1	0.1944
p.N483K	DO28721	OV	ICGC	DSGEET	DEG_SCF_TRCP1_1	0.1944
p.E487K	TCGA-EE-A2GO	SKCM	TCGA	DSGEET	DEG_SCF_TRCP1_1	0.0833
p.E487K	DO37823	SKCM	ICGC	DSGEET	DEG_SCF_TRCP1_1	0.0833
p.E480K	DO225253	BRCA	ICGC	DSGEET	DEG_SCF_TRCP1_1	0.2778
p.R463W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGEET	DEG_SCF_TRCP1_1	0.0556
p.R463W	ACH-002256	Leukemia	CCLE	DSGEET	DEG_SCF_TRCP1_1	0.0556
p.R463W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGEET	DEG_SCF_TRCP1_1	0.0556
p.R463Q	ACH-001719	Ovarian Cancer	CCLE	DSGEET	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08945	FACT complex subunit SSRP1	DEG_SCF_TRCP1_1	473:478	DSGEET	BTRC	0.9947	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons