DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LASTPPSS
Uniprot ID:
Q08945
Source protein:
FACT complex subunit SSRP1
Source gene:
SSRP1
Class:
DEG_SCF_FBW7_1
Location:
693:700
E3 ligase:
FBXW7
DEGRON score:
0.8732
ASA_SCORE:
92.3375
COIL:
0.9038
CONS_SCORE:
0.2396
DSS_SCORE:
0.8429
HELIX:
0.0861
FCONS_SCORE:
1.0823
RIG_SCORE:
0.5317
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S695N
TCGA-19-5956
GBM
TCGA
LASTPPSS
DEG_SCF_FBW7_1
0.5958
p.S695N
DO13863
GBM
ICGC
LASTPPSS
DEG_SCF_FBW7_1
0.5958
p.D708N
TCGA-AP-A0LM
UCEC
TCGA
LASTPPSS
DEG_SCF_FBW7_1
0.1111
p.D708N
DO222462
ESCA
ICGC
LASTPPSS
DEG_SCF_FBW7_1
0.1111
p.D708N
DO43306
UCEC
ICGC
LASTPPSS
DEG_SCF_FBW7_1
0.1111
p.A704V
TCGA-AX-A06F
UCEC
TCGA
LASTPPSS
DEG_SCF_FBW7_1
0.2222
p.A704V
DO41752
UCEC
ICGC
LASTPPSS
DEG_SCF_FBW7_1
0.2222
p.S699G
TCGA-B5-A3FA
UCEC
TCGA
LASTPPSS
DEG_SCF_FBW7_1
0.6993
p.S699G
DO52402
UCEC
ICGC
LASTPPSS
DEG_SCF_FBW7_1
0.6993
p.E701Q
TCGA-E9-A1NA
BRCA
TCGA
LASTPPSS
DEG_SCF_FBW7_1
0.3056
p.E701Q
DO1522
BRCA
ICGC
LASTPPSS
DEG_SCF_FBW7_1
0.3056
p.S707Y
DO229018
LICA
ICGC
LASTPPSS
DEG_SCF_FBW7_1
0.1389
p.P697T
DO229027
LICA
ICGC
LASTPPSS
DEG_SCF_FBW7_1
0.7031
p.P697H
DO229006
LICA
ICGC
LASTPPSS
DEG_SCF_FBW7_1
0.7694
p.E692Q
SIDM00620
Glioblastoma
GDSC
LASTPPSS
DEG_SCF_FBW7_1
0.3056
p.E692Q
D-336MG
central_nervous_system
COSMIC
LASTPPSS
DEG_SCF_FBW7_1
0.3056
p.T696I
SIDM00272
Breast Carcinoma
GDSC
LASTPPSS
DEG_SCF_FBW7_1
0.8189
p.T696I
ACH-000910
Breast Cancer
CCLE
LASTPPSS
DEG_SCF_FBW7_1
0.8189
p.T696I
MDA-MB-453
breast
COSMIC
LASTPPSS
DEG_SCF_FBW7_1
0.8189
Drug responses associated with SSRP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LASTPPSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q08945
FACT complex subunit SSRP1
DEG_SCF_FBW7_1
693:700
LASTPPSS
FBXW7
0.8732
More...