DegronMD

Uniprot ID: Q08945

Source protein: FACT complex subunit SSRP1

Source gene: SSRP1

Class: DEG_Kelch_Keap1_1

Location: 471:476

E3 ligase: KEAP1

DEGRON score: 0.9964

ASA_SCORE: 73.85

COIL: 0.8373

CONS_SCORE: 0.4749

DSS_SCORE: 0.8703

HELIX: 0.1237

FCONS_SCORE: 1.2224

RIG_SCORE: 0.5372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K461N	TCGA-19-5956	GBM	TCGA	SDDSGE	DEG_Kelch_Keap1_1	0.1667
p.K461N	DO13863	GBM	ICGC	SDDSGE	DEG_Kelch_Keap1_1	0.1667
p.N483K	TCGA-42-2582	OV	TCGA	SDDSGE	DEG_Kelch_Keap1_1	0.1389
p.N483K	TCGA-56-7823	LUSC	TCGA	SDDSGE	DEG_Kelch_Keap1_1	0.1389
p.N483K	DO223721	LUSC	ICGC	SDDSGE	DEG_Kelch_Keap1_1	0.1389
p.N483K	DO28721	OV	ICGC	SDDSGE	DEG_Kelch_Keap1_1	0.1389
p.E480K	DO225253	BRCA	ICGC	SDDSGE	DEG_Kelch_Keap1_1	0.2222
p.R463W	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SDDSGE	DEG_Kelch_Keap1_1	0.1111
p.R463W	ACH-002256	Leukemia	CCLE	SDDSGE	DEG_Kelch_Keap1_1	0.1111
p.R463W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SDDSGE	DEG_Kelch_Keap1_1	0.1111
p.R463Q	ACH-001719	Ovarian Cancer	CCLE	SDDSGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08945	FACT complex subunit SSRP1	DEG_Kelch_Keap1_1	471:476	SDDSGE	KEAP1	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons