DegronMD - O14492(SH2B2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q557H	TCGA-DZ-6133	KIRP	TCGA	ASSSS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.0833
p.Q557H	DO20762	KIRP	ICGC	ASSSS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.0833
p.A631V	DO222755	COCA	ICGC	RAVENQYS	CBL_APS	623:630	Mutation rewiring degron network	0.3056
p.H367R	DO234230	ESAD	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8244
p.E377A	DO231955	LICA	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.25
p.R370I	DO45057	LINC	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.8102
p.V364L	DO231026	LUSC	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2778
p.E383Q	DO27208	LUSC	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0833
p.T358P	DO220877	MELA	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.1111
p.A638T	DO232761	PBCA	ICGC	RAVENQYS	CBL_APS	623:630	Mutation rewiring degron network	0.1111
p.S384T	DO38380	STAD	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0556
p.T362A	DO38380	STAD	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.2222
p.A569V	DO229167	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	566:570	Mutation altering degron motif	0.6936
p.G568D	SIDM00411	Pancreatic Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	566:570	Mutation altering degron motif	0.7198
p.A573T	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	571:575	Mutation altering degron motif	0.7139
p.S634C	SIDM00333	Endometrial Carcinoma	GDSC	RAVENQYS	CBL_APS	623:630	Mutation rewiring degron network	0.2222
p.V629I	SIDM00879	Breast Carcinoma	GDSC	RAVENQYS	CBL_APS	623:630	Mutation altering degron motif	0.7076
p.A372T	SIDM00143	Small Cell Lung Carcinoma	GDSC	VRESLIHVP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.7139
p.A624S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	RAVENQYS	CBL_APS	623:630	Mutation altering degron motif	0.7588
p.P578L	SIDM01086	B-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1111
p.P578L	SIDM01086	B-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	571:575	Mutation rewiring degron network	0.25
p.P571L	SIDM01561	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	571:575	Mutation altering degron motif	0.7582
p.V625I	ACH-000349	Breast Cancer	CCLE	RAVENQYS	CBL_APS	623:630	Mutation altering degron motif	0.5965
p.G582D	ACH-000619	Head and Neck Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	571:575	Mutation rewiring degron network	0.1389
p.A569T	ACH-000823	Esophageal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	566:570	Mutation altering degron motif	0.7139
p.P574L	ACH-000874	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	571:575	Mutation altering degron motif	0.7582
p.P356A	ACH-000890	Lung Cancer	CCLE	VRESLIHVP	DEG_APCC_DBOX_1	366:374	Mutation rewiring degron network	0.0556
p.H367Y	ACH-000979	Prostate Cancer	CCLE	VRESLIHVP	DEG_APCC_DBOX_1	366:374	Mutation altering degron motif	0.7229

Kaplan plot for SH2B2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH2B2

UniProt ID: O14492

Entrez ID: 10603

Protein name: SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH2B2 in