DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
RAVENQYS
Uniprot ID:
O14492
Source protein:
SH2B adapter protein 2
Source gene:
SH2B2
Class:
CBL_APS
Location:
623:630
E3 ligase:
CBL
DEGRON score:
0.9938
ASA_SCORE:
52.825
COIL:
0.4926
CONS_SCORE:
0.6511
DSS_SCORE:
0.6111
HELIX:
0.0885
FCONS_SCORE:
1.7585
RIG_SCORE:
0.7545
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A631V
DO222755
COCA
ICGC
RAVENQYS
CBL_APS
0.3056
p.A638T
DO232761
PBCA
ICGC
RAVENQYS
CBL_APS
0.1111
p.S634C
SIDM00333
Endometrial Carcinoma
GDSC
RAVENQYS
CBL_APS
0.2222
p.V629I
SIDM00879
Breast Carcinoma
GDSC
RAVENQYS
CBL_APS
0.7076
p.A624S
SIDM00114
Non-Small Cell Lung Carcinoma
GDSC
RAVENQYS
CBL_APS
0.7588
p.V625I
ACH-000349
Breast Cancer
CCLE
RAVENQYS
CBL_APS
0.5965
Drug responses associated with SH2B2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RAVENQYS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14492
SH2B adapter protein 2
CBL_APS
623:630
RAVENQYS
CBL
0.9938
More...
