DegronMD

Uniprot ID: O14492

Source protein: SH2B adapter protein 2

Source gene: SH2B2

Class: DEG_APCC_DBOX_1

Location: 366:374

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8704

ASA_SCORE: 67.0222

COIL: 0.6679

CONS_SCORE: 0.4725

DSS_SCORE: 0.4867

HELIX: 0.2513

FCONS_SCORE: 1.146

RIG_SCORE: 0.8003

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H367R	DO234230	ESAD	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	0.8244
p.E377A	DO231955	LICA	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	0.25
p.R370I	DO45057	LINC	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	0.8102
p.V364L	DO231026	LUSC	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	0.2778
p.E383Q	DO27208	LUSC	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	0.0833
p.T358P	DO220877	MELA	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	0.1111
p.S384T	DO38380	STAD	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	0.0556
p.T362A	DO38380	STAD	ICGC	VRESLIHVP	DEG_APCC_DBOX_1	0.2222
p.A372T	SIDM00143	Small Cell Lung Carcinoma	GDSC	VRESLIHVP	DEG_APCC_DBOX_1	0.7139
p.P356A	ACH-000890	Lung Cancer	CCLE	VRESLIHVP	DEG_APCC_DBOX_1	0.0556
p.H367Y	ACH-000979	Prostate Cancer	CCLE	VRESLIHVP	DEG_APCC_DBOX_1	0.7229

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14492	SH2B adapter protein 2	DEG_APCC_DBOX_1	366:374	VRESLIHVP	APC,CDC20,FZR1	0.8704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons