DegronMD - Q92833(JARID2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D94H	TCGA-50-5930	LUAD	TCGA	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2778
p.D94H	DO25189	LUAD	ICGC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2778
p.K240I	TCGA-86-6851	LUAD	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation substituting flanking lysine	0.3611
p.A249T	TCGA-A5-A0G1	UCEC	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation altering degron motif	0.6028
p.S1243L	TCGA-A5-A2K5	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1242:1246	Mutation altering degron motif	0.6556
p.S1243L	TCGA-DK-A6AW	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	1242:1246	Mutation altering degron motif	0.6556
p.S1243L	TCGA-FI-A2D5	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1242:1246	Mutation altering degron motif	0.6556
p.A246T	TCGA-AP-A051	UCEC	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation altering degron motif	0.6028
p.G763S	TCGA-B5-A11L	UCEC	TCGA	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.1389
p.R257W	TCGA-B5-A1MX	UCEC	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.1389
p.P1230S	TCGA-BR-4257	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.1944
p.P248L	TCGA-D3-A51F	SKCM	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation altering degron motif	0.7582
p.A765V	TCGA-D5-6530	COAD	TCGA	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.1944
p.V1228M	TCGA-EY-A1GU	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.1389
p.V1228M	SIDM00596	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.1389
p.R233L	TCGA-FS-A1Z0	SKCM	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.0556
p.R233Q	TCGA-FW-A3R5	SKCM	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.0556
p.R233Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.0556
p.R233Q	ACH-000795	Leukemia	CCLE	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.0556
p.R233Q	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.0556
p.S1245P	TCGA-HU-A4H3	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1242:1246	Mutation altering degron motif	0.6752
p.S90P	TCGA-R5-A7ZI	STAD	TCGA	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.6752
p.S90P	DO222342	STAD	ICGC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.6752
p.S245L	DO554	BLCA	ICGC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation altering degron motif	0.7667
p.R253Q	DO3662	BRCA	ICGC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.25
p.R85W	DO230312	COCA	ICGC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.25
p.R85W	DO41999	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.25
p.E762A	DO227985	COCA	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.1111
p.A782V	DO234320	ESAD	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.2222
p.N96Y	DO233251	GACA	ICGC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2222
p.A100V	DO233882	GACA	ICGC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1111
p.R256Q	DO52109	HNSC	ICGC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.1667
p.A86S	DO228974	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation blocking phosphorylation signal	0.7222
p.A99S	DO229029	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1389
p.D94Y	DO229024	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2778
p.G772C	DO229031	LICA	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.76
p.G772C	DO229034	LICA	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.76
p.K80N	DO229036	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.1111
p.D94N	DO229051	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.2778
p.E785K	DO229051	LICA	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.1389
p.N233S	DO231518	LINC	ICGC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.0556
p.E784K	DO47368	SKCM	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.1667
p.T771A	DO229268	THCA	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.7139
p.I776M	DO50075	UCEC	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.7618
p.S90C	SIDM01123	Prostate Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.7541
p.S90C	ACH-000177	Prostate Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.7541
p.S90C	NCI-H660	prostate	COSMIC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.7541
p.Q239P	SIDM01126	Small Cell Lung Carcinoma	GDSC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.2222
p.Q239P	SIDM01147	Gastric Carcinoma	GDSC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.2222
p.Q239P	SIDM00793	Burkitt's Lymphoma	GDSC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.2222
p.P766H	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.2222
p.P766H	ACH-000860	Lung Cancer	CCLE	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.2222
p.P766H	NCI-H358	lung	COSMIC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.2222
p.E102K	SIDM00803	Kidney Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0556
p.E102K	ACH-000411	Kidney Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0556
p.E102K	769-P	kidney	COSMIC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation rewiring degron network	0.0556
p.G769S	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.3056
p.G769S	ACH-000873	Esophageal Cancer	CCLE	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.3056
p.G769S	KYSE-270	oesophagus	COSMIC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.3056
p.K240E	SIDM00132	Pancreatic Carcinoma	GDSC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation substituting flanking lysine	0.3611
p.K240E	ACH-000535	Pancreatic Cancer	CCLE	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation substituting flanking lysine	0.3611
p.K240E	BxPC-3	pancreas	COSMIC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation substituting flanking lysine	0.3611
p.G251W	NCI-SNU-1	stomach	COSMIC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.3056
p.P764T	NUGC-3	stomach	COSMIC	FRSKLKEVG	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.1667
p.Q260R	EN	endometrium	COSMIC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation rewiring degron network	0.0556
p.R89P	UM-UC-3	urinary tract	COSMIC	VSSTS	DEG_SPOP_SBC_1	88:92	Mutation altering degron motif	0.7512
p.V250G	KCL-22	haematopoietic and lymphoid tissue	COSMIC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	243:250	Mutation altering degron motif	0.7532

Kaplan plot for JARID2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JARID2

UniProt ID: Q92833

Entrez ID: 3720

Protein name: Protein Jumonji (Jumonji/ARID domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JARID2 in