DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SKEATPAK
Uniprot ID:
Q92833
Source protein:
Protein Jumonji
Source gene:
JARID2
Class:
DEG_SCF_SKP2-CKS1_1
Location:
243:250
E3 ligase:
SKP2,CSK1
DEGRON score:
0.774
ASA_SCORE:
97.15
COIL:
0.7129
CONS_SCORE:
0.3251
DSS_SCORE:
0.8622
HELIX:
0.272
FCONS_SCORE:
0.9702
RIG_SCORE:
0.5803
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S245L
DO554
BLCA
ICGC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.7667
p.P248L
TCGA-D3-A51F
SKCM
TCGA
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.7582
p.V250G
KCL-22
haematopoietic_and_lymphoid_tissue
COSMIC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.7532
p.A249T
TCGA-A5-A0G1
UCEC
TCGA
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.6028
p.A246T
TCGA-AP-A051
UCEC
TCGA
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.6028
p.K240I
TCGA-86-6851
LUAD
TCGA
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.3611
p.K240E
SIDM00132
Pancreatic Carcinoma
GDSC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.3611
p.K240E
ACH-000535
Pancreatic Cancer
CCLE
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.3611
p.K240E
BxPC-3
pancreas
COSMIC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.3611
p.G251W
NCI-SNU-1
stomach
COSMIC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.3056
p.R253Q
DO3662
BRCA
ICGC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.25
p.Q239P
SIDM01126
Small Cell Lung Carcinoma
GDSC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.2222
p.Q239P
SIDM01147
Gastric Carcinoma
GDSC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.2222
p.Q239P
SIDM00793
Burkitt's Lymphoma
GDSC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.2222
p.R256Q
DO52109
HNSC
ICGC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.1667
p.R257W
TCGA-B5-A1MX
UCEC
TCGA
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.1389
p.R233L
TCGA-FS-A1Z0
SKCM
TCGA
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.0556
p.R233Q
TCGA-FW-A3R5
SKCM
TCGA
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.0556
p.R233Q
SIDM00433
T-Lymphoblastic Leukemia
GDSC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.0556
p.R233Q
ACH-000795
Leukemia
CCLE
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.0556
p.R233Q
MOLT-13
haematopoietic_and_lymphoid_tissue
COSMIC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.0556
p.N233S
DO231518
LINC
ICGC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.0556
p.Q260R
EN
endometrium
COSMIC
SKEATPAK
DEG_SCF_SKP2-CKS1_1
0.0556
Showing 1 to 23 of 23 entries
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Drug responses associated with JARID2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of SKEATPAK
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92833
Protein Jumonji
DEG_SCF_SKP2-CKS1_1
243:250
SKEATPAK
SKP2,CSK1
0.774
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