DegronMD

Uniprot ID: Q92833

Source protein: Protein Jumonji

Source gene: JARID2

Class: DEG_SCF_SKP2-CKS1_1

Location: 243:250

E3 ligase: SKP2,CSK1

DEGRON score: 0.774

ASA_SCORE: 97.15

COIL: 0.7129

CONS_SCORE: 0.3251

DSS_SCORE: 0.8622

HELIX: 0.272

FCONS_SCORE: 0.9702

RIG_SCORE: 0.5803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K240I	TCGA-86-6851	LUAD	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.3611
p.A249T	TCGA-A5-A0G1	UCEC	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A246T	TCGA-AP-A051	UCEC	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.6028
p.R257W	TCGA-B5-A1MX	UCEC	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P248L	TCGA-D3-A51F	SKCM	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.7582
p.R233L	TCGA-FS-A1Z0	SKCM	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R233Q	TCGA-FW-A3R5	SKCM	TCGA	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R233Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R233Q	ACH-000795	Leukemia	CCLE	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R233Q	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S245L	DO554	BLCA	ICGC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.7667
p.R253Q	DO3662	BRCA	ICGC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.25
p.R256Q	DO52109	HNSC	ICGC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.1667
p.N233S	DO231518	LINC	ICGC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.Q239P	SIDM01126	Small Cell Lung Carcinoma	GDSC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.Q239P	SIDM01147	Gastric Carcinoma	GDSC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.Q239P	SIDM00793	Burkitt's Lymphoma	GDSC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.2222
p.K240E	SIDM00132	Pancreatic Carcinoma	GDSC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.3611
p.K240E	ACH-000535	Pancreatic Cancer	CCLE	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.3611
p.K240E	BxPC-3	pancreas	COSMIC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.3611
p.G251W	NCI-SNU-1	stomach	COSMIC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.3056
p.Q260R	EN	endometrium	COSMIC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.0556
p.V250G	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	SKEATPAK	DEG_SCF_SKP2-CKS1_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92833	Protein Jumonji	DEG_SCF_SKP2-CKS1_1	243:250	SKEATPAK	SKP2,CSK1	0.774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKEATPAK

Degron related mutations and impact score

Drug responses associated with JARID2 mutations

All proteins holding degron of SKEATPAK