DegronMD

Uniprot ID: Q92833

Source protein: Protein Jumonji

Source gene: JARID2

Class: DEG_APCC_DBOX_1

Location: 770:778

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9226

ASA_SCORE: 74.3

COIL: 0.5196

CONS_SCORE: 0.375

DSS_SCORE: 0.5085

HELIX: 0.2257

FCONS_SCORE: 1.4282

RIG_SCORE: 0.7448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G763S	TCGA-B5-A11L	UCEC	TCGA	FRSKLKEVG	DEG_APCC_DBOX_1	0.1389
p.A765V	TCGA-D5-6530	COAD	TCGA	FRSKLKEVG	DEG_APCC_DBOX_1	0.1944
p.E762A	DO227985	COCA	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	0.1111
p.A782V	DO234320	ESAD	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	0.2222
p.G772C	DO229031	LICA	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	0.76
p.G772C	DO229034	LICA	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	0.76
p.E785K	DO229051	LICA	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	0.1389
p.E784K	DO47368	SKCM	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	0.1667
p.T771A	DO229268	THCA	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	0.7139
p.I776M	DO50075	UCEC	ICGC	FRSKLKEVG	DEG_APCC_DBOX_1	0.7618
p.P766H	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	FRSKLKEVG	DEG_APCC_DBOX_1	0.2222
p.P766H	ACH-000860	Lung Cancer	CCLE	FRSKLKEVG	DEG_APCC_DBOX_1	0.2222
p.P766H	NCI-H358	lung	COSMIC	FRSKLKEVG	DEG_APCC_DBOX_1	0.2222
p.G769S	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	FRSKLKEVG	DEG_APCC_DBOX_1	0.3056
p.G769S	ACH-000873	Esophageal Cancer	CCLE	FRSKLKEVG	DEG_APCC_DBOX_1	0.3056
p.G769S	KYSE-270	oesophagus	COSMIC	FRSKLKEVG	DEG_APCC_DBOX_1	0.3056
p.P764T	NUGC-3	stomach	COSMIC	FRSKLKEVG	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92833	Protein Jumonji	DEG_APCC_DBOX_1	770:778	FRSKLKEVG	APC,CDC20,FZR1	0.9226	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons