DegronMD - Q9UJ98(STAG3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1113M	TCGA-A5-A0VP	UCEC	TCGA	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.2778
p.V1113M	TCGA-A5-A0VP	UCEC	TCGA	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation rewiring degron network	0.2222
p.V1113M	DO42600	UCEC	ICGC	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.2778
p.V1113M	DO42600	UCEC	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation rewiring degron network	0.2222
p.P1104S	TCGA-AB-2828	LAML	TCGA	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation altering degron motif	0.5641
p.P1104S	DO21571	LAML	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation altering degron motif	0.5641
p.D1129Y	TCGA-AP-A0LM	UCEC	TCGA	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.1667
p.D1129Y	DO43306	UCEC	ICGC	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.1667
p.K13N	TCGA-BA-4077	HNSC	TCGA	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation substituting flanking lysine	0.3056
p.K13N	DO15647	HNSC	ICGC	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation substituting flanking lysine	0.3056
p.Q1098H	TCGA-DX-A6YV	SARC	TCGA	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation rewiring degron network	0.2222
p.Q1098H	DO220011	SARC	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation rewiring degron network	0.2222
p.Q1098H	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation rewiring degron network	0.2222
p.M1125I	TCGA-EE-A2MR	SKCM	TCGA	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.2778
p.M1125I	DO37819	SKCM	ICGC	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.2778
p.E1126V	TCGA-EE-A2MR	SKCM	TCGA	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.25
p.E1126V	DO37819	SKCM	ICGC	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.25
p.P1104L	TCGA-MP-A4TC	LUAD	TCGA	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation altering degron motif	0.6471
p.P1104L	DO45342	LUAD	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation altering degron motif	0.6471
p.K1114N	DO225096	BRCA	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation substituting flanking lysine	0.3056
p.A24V	DO222443	BTCA	ICGC	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2778
p.R14K	DO228193	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2222
p.A24S	DO229037	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2778
p.T1105M	DO229081	PRAD	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation altering degron motif	0.7423
p.A1112P	DO50424	PRAD	ICGC	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.25
p.A1112P	DO50424	PRAD	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation rewiring degron network	0.25
p.D30E	SIDM00350	Head and Neck Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1111
p.D30E	SIDM01320	Pancreatic Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1111
p.D30E	ACH-000468	Pancreatic Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1111
p.D30E	ACH-001197	Lymphoma	CCLE	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1111
p.D30E	ACH-001641	Head and Neck Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1111
p.D30E	SAT	upper aerodigestive tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1111
p.E1095G	SIDM00878	Breast Carcinoma	GDSC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation rewiring degron network	0.1389
p.E1095G	ACH-000930	Breast Cancer	CCLE	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation rewiring degron network	0.1389
p.E1095G	HCC1569	breast	COSMIC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation rewiring degron network	0.1389
p.I1102N	SIDM00983	Bladder Carcinoma	GDSC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation altering degron motif	0.728
p.I1102N	ACH-000896	Bladder Cancer	CCLE	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation altering degron motif	0.728
p.I1102N	647-V	urinary tract	COSMIC	IPPTPTLT	DEG_SCF_FBW7_1	1102:1109	Mutation altering degron motif	0.728
p.R1116W	SIDM00983	Bladder Carcinoma	GDSC	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.8634
p.R1116W	ACH-000896	Bladder Cancer	CCLE	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.8634
p.R1116W	647-V	urinary tract	COSMIC	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.8634
p.S25G	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.S25G	ACH-000744	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.S25G	NCI-H1623	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.E1124Q	ACH-000975	Lung Cancer	CCLE	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation rewiring degron network	0.3056
p.E1122G	SNU-1040	large intestine	COSMIC	SRQPLWGLK	DEG_APCC_DBOX_1	1115:1123	Mutation altering degron motif	0.7199

Kaplan plot for STAG3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STAG3

UniProt ID: Q9UJ98

Entrez ID: 10734

Protein name: Cohesin subunit SA-3 (SCC3 homolog 3) (Stromal antigen 3) (Stromalin-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STAG3 in