DegronMD

Uniprot ID: Q9UJ98

Source protein: Cohesin subunit SA-3

Source gene: STAG3

Class: DEG_SCF_FBW7_1

Location: 1102:1109

E3 ligase: FBXW7

DEGRON score: 0.9856

ASA_SCORE: 91.3

COIL: 0.955

CONS_SCORE: 0.2423

DSS_SCORE: 0.6139

HELIX: 0.0174

FCONS_SCORE: 1.0296

RIG_SCORE: 0.6461

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1113M	TCGA-A5-A0VP	UCEC	TCGA	IPPTPTLT	DEG_SCF_FBW7_1	0.2222
p.V1113M	DO42600	UCEC	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	0.2222
p.P1104S	TCGA-AB-2828	LAML	TCGA	IPPTPTLT	DEG_SCF_FBW7_1	0.5641
p.P1104S	DO21571	LAML	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	0.5641
p.Q1098H	TCGA-DX-A6YV	SARC	TCGA	IPPTPTLT	DEG_SCF_FBW7_1	0.2222
p.Q1098H	DO220011	SARC	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	0.2222
p.Q1098H	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	IPPTPTLT	DEG_SCF_FBW7_1	0.2222
p.P1104L	TCGA-MP-A4TC	LUAD	TCGA	IPPTPTLT	DEG_SCF_FBW7_1	0.6471
p.P1104L	DO45342	LUAD	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	0.6471
p.K1114N	DO225096	BRCA	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	0.3056
p.T1105M	DO229081	PRAD	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	0.7423
p.A1112P	DO50424	PRAD	ICGC	IPPTPTLT	DEG_SCF_FBW7_1	0.25
p.E1095G	SIDM00878	Breast Carcinoma	GDSC	IPPTPTLT	DEG_SCF_FBW7_1	0.1389
p.E1095G	ACH-000930	Breast Cancer	CCLE	IPPTPTLT	DEG_SCF_FBW7_1	0.1389
p.E1095G	HCC1569	breast	COSMIC	IPPTPTLT	DEG_SCF_FBW7_1	0.1389
p.I1102N	SIDM00983	Bladder Carcinoma	GDSC	IPPTPTLT	DEG_SCF_FBW7_1	0.728
p.I1102N	ACH-000896	Bladder Cancer	CCLE	IPPTPTLT	DEG_SCF_FBW7_1	0.728
p.I1102N	647-V	urinary_tract	COSMIC	IPPTPTLT	DEG_SCF_FBW7_1	0.728

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJ98	Cohesin subunit SA-3	DEG_SCF_FBW7_1	1102:1109	IPPTPTLT	FBXW7	0.9856	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons