DegronMD

Uniprot ID: Q9UJ98

Source protein: Cohesin subunit SA-3

Source gene: STAG3

Class: DEG_APCC_DBOX_1

Location: 1115:1123

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9943

ASA_SCORE: 104.7556

COIL: 0.7824

CONS_SCORE: 0.2543

DSS_SCORE: 0.5514

HELIX: 0.196

FCONS_SCORE: 1.1132

RIG_SCORE: 0.7406

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1113M	TCGA-A5-A0VP	UCEC	TCGA	SRQPLWGLK	DEG_APCC_DBOX_1	0.2778
p.V1113M	DO42600	UCEC	ICGC	SRQPLWGLK	DEG_APCC_DBOX_1	0.2778
p.D1129Y	TCGA-AP-A0LM	UCEC	TCGA	SRQPLWGLK	DEG_APCC_DBOX_1	0.1667
p.D1129Y	DO43306	UCEC	ICGC	SRQPLWGLK	DEG_APCC_DBOX_1	0.1667
p.M1125I	TCGA-EE-A2MR	SKCM	TCGA	SRQPLWGLK	DEG_APCC_DBOX_1	0.2778
p.M1125I	DO37819	SKCM	ICGC	SRQPLWGLK	DEG_APCC_DBOX_1	0.2778
p.E1126V	TCGA-EE-A2MR	SKCM	TCGA	SRQPLWGLK	DEG_APCC_DBOX_1	0.25
p.E1126V	DO37819	SKCM	ICGC	SRQPLWGLK	DEG_APCC_DBOX_1	0.25
p.A1112P	DO50424	PRAD	ICGC	SRQPLWGLK	DEG_APCC_DBOX_1	0.25
p.R1116W	SIDM00983	Bladder Carcinoma	GDSC	SRQPLWGLK	DEG_APCC_DBOX_1	0.8634
p.R1116W	ACH-000896	Bladder Cancer	CCLE	SRQPLWGLK	DEG_APCC_DBOX_1	0.8634
p.R1116W	647-V	urinary_tract	COSMIC	SRQPLWGLK	DEG_APCC_DBOX_1	0.8634
p.E1124Q	ACH-000975	Lung Cancer	CCLE	SRQPLWGLK	DEG_APCC_DBOX_1	0.3056
p.E1122G	SNU-1040	large_intestine	COSMIC	SRQPLWGLK	DEG_APCC_DBOX_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJ98	Cohesin subunit SA-3	DEG_APCC_DBOX_1	1115:1123	SRQPLWGLK	APC,CDC20,FZR1	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons