DegronMD

Uniprot ID: P08069

Source protein: Insulin-like growth factor 1 receptor

Source gene: IGF1R

Class: DEG_SPOP_SBC_1

Location: 1309:1313

E3 ligase: SPOP

DEGRON score: 0.9782

ASA_SCORE: 71

COIL: 0.9272

CONS_SCORE: 0.3438

DSS_SCORE: 0.6988

HELIX: 0.0628

FCONS_SCORE: 0.7738

RIG_SCORE: 0.5256

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1313F	TCGA-BH-A0HF	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	0.9093
p.V1303I	TCGA-CN-4740	HNSC	TCGA	ASSSS	DEG_SPOP_SBC_1	0.1667
p.V1303I	SIDM00999	Bladder Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	0.1667
p.P1304H	TCGA-D3-A1Q1	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	0.1944
p.R1319T	TCGA-DU-A7T6	LGG	TCGA	ASSSS	DEG_SPOP_SBC_1	0.1667
p.S1312F	DO1749	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	0.9093
p.M1299I	DO233646	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	0.0556
p.S1310A	DO233840	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	0.7588
p.V1302I	DO14846	HNSC	ICGC	ASSSS	DEG_SPOP_SBC_1	0.1389
p.V1302I	ACH-000973	Bladder Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	0.1389
p.R1318T	DO51814	LGG	ICGC	ASSSS	DEG_SPOP_SBC_1	0.1944
p.G1321E	DO231941	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	0.5556
p.S1307A	DO228405	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	0.2778
p.S1301I	DO229024	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	0.1111
p.S1312P	DO45055	LINC	ICGC	ASSSS	DEG_SPOP_SBC_1	0.7863
p.P1303H	DO37445	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	0.1667
p.S1308L	SIDM00217	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	0.3056
p.S1308L	SNU-1040	large_intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.3056
p.D1318N	SIDM01228	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	0.1944
p.D1318N	CHL-1	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.1944
p.D1317N	ACH-000931	Skin Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	0.2222
p.D1317N	ACH-001024	Skin Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	0.2222
p.D1317N	ACH-001041	Skin Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	0.2222
p.D1317N	CHL-1	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.2222
p.S1307L	ACH-000999	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	0.2778
p.S1307L	SNU-1040	large_intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.2778
p.S1311L	SNU-1040	large_intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.8778
p.S1310L	SNU-1040	large_intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.7667

Drug responses associated with IGF1R mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000065	Leukemia	p.L17V (No)	CCLE	AEW541	1.2382
ACH-000879	Endometrial/Uterine Cancer	p.D38N (No)	CCLE	AEW541	7.5018
ACH-000978	Endometrial/Uterine Cancer	p.L133P (No)	CCLE	AEW541	8
ACH-000599	Pancreatic Cancer	p.D162N (No)	CCLE	AEW541	3.1226
ACH-000014	Metastasis	p.A241T (No)	CCLE	AEW541	3.6686
ACH-000974	Endometrial/Uterine Cancer	p.R252C (No)	CCLE	AEW541	8
ACH-000960	Leukemia	p.V259I (No)	CCLE	AEW541	4.6579
ACH-000973	Bladder Cancer	p.R275C (No)	CCLE	AEW541	1.7362
ACH-000721	Breast Cancer	p.I298F (No)	CCLE	AEW541	3.8056
ACH-000366	Neuroblastoma	p.L360F (No)	CCLE	AEW541	1.3
ACH-000841	Lung Cancer	p.G410V (No)	CCLE	AEW541	7.7227
ACH-000985	Colon/Colorectal Cancer	p.R461H (No)	CCLE	AEW541	2.9961
ACH-000245	Lymphoma	p.V554M (No)	CCLE	AEW541	8
ACH-000994	Endometrial/Uterine Cancer	p.I594V (No)	CCLE	AEW541	8
ACH-000978	Endometrial/Uterine Cancer	p.K630R (No)	CCLE	AEW541	8
ACH-000960	Leukemia	p.T758M (No)	CCLE	AEW541	4.6579
ACH-000997	Colon/Colorectal Cancer	p.N792D (No)	CCLE	AEW541	4.6306
ACH-000958	Colon/Colorectal Cancer	p.A828T (No)	CCLE	AEW541	0.6875
ACH-000994	Endometrial/Uterine Cancer	p.R904Q (No)	CCLE	AEW541	8
ACH-000979	Prostate Cancer	p.S909fs (No)	CCLE	AEW541	6.6821
ACH-000994	Endometrial/Uterine Cancer	p.A938T (No)	CCLE	AEW541	8
ACH-000966	Ovarian Cancer	p.V942I (No)	CCLE	AEW541	8
ACH-000987	Skin Cancer	p.P989S (No)	CCLE	AEW541	8
ACH-000587	Lung Cancer	p.E1037K (No)	CCLE	AEW541	8
ACH-000728	Leukemia	p.R1041C (No)	CCLE	AEW541	6.6841
ACH-000997	Colon/Colorectal Cancer	p.S1093F (No)	CCLE	AEW541	4.6306
ACH-000183	Myeloma	p.D1146N (No)	CCLE	AEW541	0.5981
ACH-000997	Colon/Colorectal Cancer	p.R1246C (No)	CCLE	AEW541	4.6306
ACH-000918	Leukemia	p.I1266T (No)	CCLE	AEW541	5.8091
ACH-000789	Lung Cancer	p.E1289* (No)	CCLE	AEW541	2.8553
ACH-000973	Bladder Cancer	p.V1303I (Yes)	CCLE	AEW541	1.7362
ACH-000931	Skin Cancer	p.D1317N (Yes)	CCLE	AEW541	5.2392
ACH-001024	Skin Cancer	p.D1317N (Yes)	CCLE	AEW541	7.182
ACH-001041	Lung Cancer	p.D1317N (Yes)	CCLE	AEW541	2.2132
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	BMS-536924	18.6094
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	BMS-754807	0.9746
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	Linsitinib	11.1403
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	GSK1904529A	4.8207
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	BMS-536924	16.3469
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	BMS-536924	10.922
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	GSK1904529A	18.74
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	Linsitinib	28.659
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	NVP-ADW742	9.5311
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G929E (No)	GDSC	BMS-754807	3.4953
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G929E (No)	GDSC	Linsitinib	9.7517
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G929E (No)	GDSC	GSK1904529A	4.002
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G929E (No)	GDSC	BMS-536924	5.2177
SIDM00515	SKCM\|melanoma	p.E772K (No)	GDSC	BMS-536924	53.8366
SIDM00515	SKCM\|melanoma	p.E772K (No)	GDSC	BMS-754807	1.1705
SIDM00515	SKCM\|melanoma	p.E772K (No)	GDSC	BMS-536924	1.1315
SIDM01228	SKCM\|melanoma	p.D1318N (Yes)	GDSC	BMS-754807	3.0165
SIDM01228	SKCM\|melanoma	p.D1318N (Yes)	GDSC	Linsitinib	25.6441
SIDM01228	SKCM\|melanoma	p.D1318N (Yes)	GDSC	GSK1904529A	7.6116
SIDM01228	SKCM\|melanoma	p.D1318N (Yes)	GDSC	BMS-536924	4.6752
SIDM01228	SKCM\|melanoma	p.D1318N (Yes)	GDSC	BMS-536924	11.19
SIDM01228	SKCM\|melanoma	p.D1318N (Yes)	GDSC	GSK1904529A	45.847
SIDM01228	SKCM\|melanoma	p.D1318N (Yes)	GDSC	Linsitinib	28.297
SIDM01228	SKCM\|melanoma	p.D1318N (Yes)	GDSC	NVP-ADW742	59.296
SIDM00151	OV\|ovary	p.V942I (No)	GDSC	BMS-536924	7.806
SIDM00151	OV\|ovary	p.V942I (No)	GDSC	BMS-536924	1.3789
SIDM00151	OV\|ovary	p.V942I (No)	GDSC	GSK1904529A	84.878
SIDM00151	OV\|ovary	p.V942I (No)	GDSC	Linsitinib	112.51
SIDM00151	OV\|ovary	p.V942I (No)	GDSC	NVP-ADW742	9.9393
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	BMS-536924	4.1048
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	BMS-754807	1.1106
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	Linsitinib	6.5289
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	GSK1904529A	5.9932
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	BMS-536924	6.0431
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	BMS-536924	18.543
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	GSK1904529A	53.026
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	Linsitinib	24.246
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	NVP-ADW742	19.863
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	BMS-754807	0.5062
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	Linsitinib	1.3486
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	GSK1904529A	15.5697
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	BMS-536924	2.6085
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	BMS-536924	8.2357
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	GSK1904529A	240.31
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	Linsitinib	23.242
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	NVP-ADW742	20.087
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	BMS-754807	1.9536
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	Linsitinib	34.1591
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	GSK1904529A	17.1578
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	BMS-536924	5.9774
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	BMS-536924	27.995
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	GSK1904529A	216.87
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	Linsitinib	189.14
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	NVP-ADW742	145.35
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	BMS-536924	0.2337
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	BMS-754807	0.0751
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	Linsitinib	0.2584
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	GSK1904529A	8.7259
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	BMS-536924	0.7533
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	GSK1904529A	73.249
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	Linsitinib	7.1126
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (Yes)	GDSC	BMS-536924	99.0113
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (Yes)	GDSC	BMS-754807	23.2593
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (Yes)	GDSC	Linsitinib	51.561
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (Yes)	GDSC	GSK1904529A	11.8548
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (Yes)	GDSC	BMS-536924	50.8325
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (Yes)	GDSC	GSK1904529A	35.294
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (Yes)	GDSC	Linsitinib	56.676
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	BMS-536924	3.2462
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	BMS-754807	1.112
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	Linsitinib	4.9193
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	GSK1904529A	7.4024
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	BMS-536924	19.685
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	BMS-536924	4.6307
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	GSK1904529A	25.097
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	Linsitinib	10.052
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	NVP-ADW742	4.2679
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	BMS-536924	2.2448
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	BMS-754807	0.9612
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	Linsitinib	29.7551
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	GSK1904529A	12.373
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	BMS-536924	11.5478
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	BMS-536924	20.545
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	GSK1904529A	154.54
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	Linsitinib	117.09
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	NVP-ADW742	6.8166
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	BMS-536924	0.3233
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	BMS-754807	0.4122
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	Linsitinib	1.1702
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	GSK1904529A	5.1935
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	BMS-536924	0.7089
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	BMS-536924	0.5274
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	GSK1904529A	21.319
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	Linsitinib	3.196
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	NVP-ADW742	5.8584
SIDM00690	HNSC\|head_and_neck	p.R794Q (No)	GDSC	BMS-754807	1.3615
SIDM00690	HNSC\|head_and_neck	p.R794Q (No)	GDSC	Linsitinib	5.1518
SIDM00690	HNSC\|head_and_neck	p.R794Q (No)	GDSC	GSK1904529A	5.2757
SIDM00690	HNSC\|head_and_neck	p.R794Q (No)	GDSC	BMS-536924	2.6847
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	BMS-754807	2.9163
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	Linsitinib	22.6958
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	GSK1904529A	16.0001
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	BMS-536924	9.3877
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	BMS-536924	13.638
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	GSK1904529A	180.02
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	Linsitinib	167.49
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	NVP-ADW742	85.828
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	BMS-536924	6.0294
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	BMS-754807	3.1338
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	Linsitinib	9.4936
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	GSK1904529A	15.4829
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	BMS-536924	55.4927
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	GSK1904529A	5391.5
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	Linsitinib	6292.2
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (No)	GDSC	BMS-754807	1.998
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (No)	GDSC	Linsitinib	19.889
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (No)	GDSC	GSK1904529A	6.1763
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (No)	GDSC	BMS-536924	13.6715
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (No)	GDSC	BMS-536924	3.7641
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (No)	GDSC	GSK1904529A	20.092
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (No)	GDSC	Linsitinib	54.855
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (No)	GDSC	NVP-ADW742	8.798
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	BMS-536924	3.6721
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	BMS-754807	20.0778
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	Linsitinib	15.7269
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	GSK1904529A	7.9336
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	BMS-536924	4.5531
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	BMS-536924	4.9315
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	GSK1904529A	8.5
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	Linsitinib	13.647
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	NVP-ADW742	6.3464
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	BMS-536924	9.9614
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	BMS-754807	5.1511
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	Linsitinib	34.2619
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	GSK1904529A	13.7092
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	BMS-536924	10.224
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	BMS-536924	5.5863
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	GSK1904529A	15.334
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	Linsitinib	60.148
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	NVP-ADW742	5.7721
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	BMS-754807	2.3791
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	Linsitinib	38.2735
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	GSK1904529A	6.4455
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	BMS-536924	29
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	BMS-536924	93.232
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	GSK1904529A	75.246
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	Linsitinib	97.889
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	NVP-ADW742	100.71
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	BMS-754807	2.3791
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	Linsitinib	38.2735
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	GSK1904529A	6.4455
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	BMS-536924	29
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	BMS-536924	93.232
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	GSK1904529A	75.246
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	Linsitinib	97.889
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	NVP-ADW742	100.71
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	BMS-754807	2.3791
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	Linsitinib	38.2735
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	GSK1904529A	6.4455
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	BMS-536924	29
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	BMS-536924	93.232
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	GSK1904529A	75.246
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	Linsitinib	97.889
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	NVP-ADW742	100.71
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	BMS-536924	1.8469
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	BMS-754807	3.8991
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	Linsitinib	4.9529
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	GSK1904529A	4.3618
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	BMS-536924	2.9752
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	BMS-536924	6.5718
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	GSK1904529A	27.544
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	Linsitinib	23.367
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	NVP-ADW742	6.4343
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	BMS-536924	1.8469
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	BMS-754807	3.8991
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	Linsitinib	4.9529
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	GSK1904529A	4.3618
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	BMS-536924	2.9752
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	BMS-536924	6.5718
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	GSK1904529A	27.544
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	Linsitinib	23.367
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	NVP-ADW742	6.4343
SIDM00217	COREAD\|large_intestine	p.R275C (No)	GDSC	BMS-536924	78.5208
SIDM00217	COREAD\|large_intestine	p.R275C (No)	GDSC	GSK1904529A	173.24
SIDM00217	COREAD\|large_intestine	p.R275C (No)	GDSC	Linsitinib	100.91
SIDM00217	COREAD\|large_intestine	p.R275C (No)	GDSC	BMS-754807	6.9063
SIDM00217	COREAD\|large_intestine	p.A395T (No)	GDSC	BMS-536924	78.5208
SIDM00217	COREAD\|large_intestine	p.A395T (No)	GDSC	GSK1904529A	173.24
SIDM00217	COREAD\|large_intestine	p.A395T (No)	GDSC	Linsitinib	100.91
SIDM00217	COREAD\|large_intestine	p.A395T (No)	GDSC	BMS-754807	6.9063
SIDM00217	COREAD\|large_intestine	p.M826I (No)	GDSC	BMS-536924	78.5208
SIDM00217	COREAD\|large_intestine	p.M826I (No)	GDSC	GSK1904529A	173.24
SIDM00217	COREAD\|large_intestine	p.M826I (No)	GDSC	Linsitinib	100.91
SIDM00217	COREAD\|large_intestine	p.M826I (No)	GDSC	BMS-754807	6.9063
SIDM00217	COREAD\|large_intestine	p.S1308L (Yes)	GDSC	BMS-536924	78.5208
SIDM00217	COREAD\|large_intestine	p.S1308L (Yes)	GDSC	GSK1904529A	173.24
SIDM00217	COREAD\|large_intestine	p.S1308L (Yes)	GDSC	Linsitinib	100.91
SIDM00217	COREAD\|large_intestine	p.S1308L (Yes)	GDSC	BMS-754807	6.9063
SIDM00217	COREAD\|large_intestine	p.S1311L (Yes)	GDSC	BMS-536924	78.5208
SIDM00217	COREAD\|large_intestine	p.S1311L (Yes)	GDSC	GSK1904529A	173.24
SIDM00217	COREAD\|large_intestine	p.S1311L (Yes)	GDSC	Linsitinib	100.91
SIDM00217	COREAD\|large_intestine	p.S1311L (Yes)	GDSC	BMS-754807	6.9063
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	BMS-536924	16.1072
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	BMS-754807	35.286
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	Linsitinib	35.106
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	GSK1904529A	14.1656
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	BMS-536924	13.5952
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	BMS-536924	10.783
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	GSK1904529A	105.88
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	Linsitinib	47.158
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	NVP-ADW742	5.5686
SIDM00216	COREAD\|large_intestine	p.T79A (No)	GDSC	BMS-536924	4.3897
SIDM00216	COREAD\|large_intestine	p.T79A (No)	GDSC	GSK1904529A	13.992
SIDM00216	COREAD\|large_intestine	p.T79A (No)	GDSC	Linsitinib	9.9234
SIDM00216	COREAD\|large_intestine	p.T79A (No)	GDSC	NVP-ADW742	11.105
SIDM00216	COREAD\|large_intestine	p.T79A (No)	GDSC	BMS-754807	0.2294
SIDM00216	COREAD\|large_intestine	p.R471C (No)	GDSC	BMS-536924	4.3897
SIDM00216	COREAD\|large_intestine	p.R471C (No)	GDSC	GSK1904529A	13.992
SIDM00216	COREAD\|large_intestine	p.R471C (No)	GDSC	Linsitinib	9.9234
SIDM00216	COREAD\|large_intestine	p.R471C (No)	GDSC	NVP-ADW742	11.105
SIDM00216	COREAD\|large_intestine	p.R471C (No)	GDSC	BMS-754807	0.2294
SIDM00216	COREAD\|large_intestine	p.R1337C (No)	GDSC	BMS-536924	4.3897
SIDM00216	COREAD\|large_intestine	p.R1337C (No)	GDSC	GSK1904529A	13.992
SIDM00216	COREAD\|large_intestine	p.R1337C (No)	GDSC	Linsitinib	9.9234
SIDM00216	COREAD\|large_intestine	p.R1337C (No)	GDSC	NVP-ADW742	11.105
SIDM00216	COREAD\|large_intestine	p.R1337C (No)	GDSC	BMS-754807	0.2294
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	BMS-754807	7.0493
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	Linsitinib	27.5972
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	GSK1904529A	6.0036
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	BMS-536924	15.7819
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	BMS-536924	27.008
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	GSK1904529A	103.37
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	Linsitinib	48.994
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	NVP-ADW742	118
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	BMS-754807	1.036
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	Linsitinib	15.1526
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	GSK1904529A	4.5646
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	BMS-536924	13.986
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	BMS-536924	2.6893
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	GSK1904529A	31.745
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	Linsitinib	41.802
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	NVP-ADW742	7.6499
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	BMS-536924	0.5436
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	BMS-754807	0.1578
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	Linsitinib	1.3628
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	GSK1904529A	2.9894
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	BMS-536924	7.0012
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	BMS-536924	1.6249
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	GSK1904529A	64.316
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	Linsitinib	31.353
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	NVP-ADW742	1.4156
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	BMS-754807	5.2852
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	BMS-536924	24.3843
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	BMS-754807	11.544
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	Linsitinib	27.0772
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	GSK1904529A	3.4053
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	BMS-536924	22.1194
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	BMS-536924	82.685
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	GSK1904529A	39.141
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	Linsitinib	76.273
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	NVP-ADW742	6.7579
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	BMS-536924	43.4589
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	BMS-754807	1.4725
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	Linsitinib	4.5956
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	GSK1904529A	12.1224
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	BMS-536924	11.2126
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	BMS-536924	4.9349
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	GSK1904529A	34.907
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	Linsitinib	8.243
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	NVP-ADW742	2.7905
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	BMS-536924	7.4357
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	BMS-754807	4.6615
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	Linsitinib	12.1847
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	GSK1904529A	7.2173
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	BMS-536924	2.5812
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	BMS-536924	10.902
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	GSK1904529A	88.947
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	Linsitinib	28.507
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	NVP-ADW742	7.2883
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	BMS-536924	7.4357
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	BMS-754807	4.6615
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	Linsitinib	12.1847
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	GSK1904529A	7.2173
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	BMS-536924	2.5812
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	BMS-536924	10.902
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	GSK1904529A	88.947
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	Linsitinib	28.507
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	NVP-ADW742	7.2883
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	BMS-536924	7.4357
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	BMS-754807	4.6615
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	Linsitinib	12.1847
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	GSK1904529A	7.2173
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	BMS-536924	2.5812
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	BMS-536924	10.902
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	GSK1904529A	88.947
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	Linsitinib	28.507
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	NVP-ADW742	7.2883
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	BMS-536924	1.8411
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	BMS-754807	14.1186
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	Linsitinib	16.9354
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	GSK1904529A	9.4919
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	BMS-536924	4.2668
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	BMS-536924	2.6318
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	GSK1904529A	164.76
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	Linsitinib	26.557
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	NVP-ADW742	6.2857
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	BMS-754807	6.9258
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	Linsitinib	40.5989
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	GSK1904529A	12.1109
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	BMS-536924	22.1767
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	BMS-536924	6.3692
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	GSK1904529A	39.342
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	Linsitinib	27.639
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	NVP-ADW742	7.9187
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	BMS-754807	2.0375
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	BMS-754807	6.9258
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	Linsitinib	40.5989
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	GSK1904529A	12.1109
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	BMS-536924	22.1767
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	BMS-536924	6.3692
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	GSK1904529A	39.342
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	Linsitinib	27.639
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	NVP-ADW742	7.9187
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	BMS-754807	2.0375
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	BMS-536924	93.0482
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	BMS-754807	25.2865
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	Linsitinib	106.4328
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	GSK1904529A	9.5272
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	BMS-536924	108.1201
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	BMS-536924	130.19
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	GSK1904529A	131.98
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	Linsitinib	534.88
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	NVP-ADW742	369.56
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.D1341N (No)	GDSC	BMS-754807	0.4216
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.D1341N (No)	GDSC	Linsitinib	1.3624
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.D1341N (No)	GDSC	GSK1904529A	11.8814
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.D1341N (No)	GDSC	BMS-536924	0.5462
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	BMS-754807	0.1555
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	Linsitinib	2.6669
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	GSK1904529A	3.0317
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	BMS-536924	40.6424
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	BMS-536924	13.706
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	GSK1904529A	68.897
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	Linsitinib	59.554
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	NVP-ADW742	23.938
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	BMS-754807	29.2901
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	Linsitinib	45.516
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	GSK1904529A	13.0642
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	BMS-536924	28.9113
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	BMS-536924	54.915
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	GSK1904529A	172.51
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	Linsitinib	486.96
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	NVP-ADW742	13.102
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	BMS-754807	1.4257
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	Linsitinib	10.7654
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	GSK1904529A	10.0918
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	BMS-536924	4.8645
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	BMS-536924	16.527
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	GSK1904529A	198.37
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	Linsitinib	40.236
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	NVP-ADW742	23.323
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	BMS-536924	3.7247
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	BMS-754807	1.6574
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	Linsitinib	8.9124
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	GSK1904529A	2.9679
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	BMS-536924	14.5536
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	BMS-536924	6.3355
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	GSK1904529A	14.63
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	Linsitinib	18.752
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	NVP-ADW742	6.1878
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	BMS-536924	0.3417
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	BMS-754807	0.4477
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	Linsitinib	1.2654
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	GSK1904529A	15.173
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	BMS-536924	3.9509
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	BMS-536924	1.0331
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	GSK1904529A	76.283
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	Linsitinib	21.166
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	NVP-ADW742	13.251
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	BMS-754807	1.0929
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	Linsitinib	16.7882
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	GSK1904529A	4.2689
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	BMS-536924	4.6204
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	BMS-536924	10.969
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	GSK1904529A	31.544
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	Linsitinib	86.74
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	NVP-ADW742	80.25
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	BMS-536924	12.7461
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	BMS-754807	1.3258
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	Linsitinib	16.0193
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	GSK1904529A	8.322
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	BMS-536924	17.8002
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	BMS-536924	41.504
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	GSK1904529A	34.246
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	Linsitinib	93.281
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	NVP-ADW742	178.58
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	BMS-754807	13.4241
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	Linsitinib	57.9789
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	GSK1904529A	22.5694
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	BMS-536924	62.2515
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	BMS-536924	74.056
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	GSK1904529A	231.15
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	Linsitinib	232.75
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	NVP-ADW742	177.07
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	BMS-754807	2.5001
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	Linsitinib	23.8447
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	GSK1904529A	8.0548
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	BMS-536924	10.3394
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	BMS-536924	47.625
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	GSK1904529A	169.4
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	Linsitinib	253.15
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	NVP-ADW742	108.28
SIDM01005	LAML\|acute_myeloid_leukaemia	p.T104M (No)	GDSC	BMS-536924	12.5028
SIDM01005	LAML\|acute_myeloid_leukaemia	p.T104M (No)	GDSC	BMS-536924	0.443
SIDM01005	LAML\|acute_myeloid_leukaemia	p.T104M (No)	GDSC	GSK1904529A	72.08
SIDM01005	LAML\|acute_myeloid_leukaemia	p.T104M (No)	GDSC	Linsitinib	14.861
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	BMS-754807	0.1226
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	Linsitinib	1.8852
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	GSK1904529A	7.4587
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	BMS-536924	5.2043
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	BMS-536924	5.8179
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	GSK1904529A	21.883
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	Linsitinib	40.694
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	NVP-ADW742	11.596
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	BMS-754807	1.0155
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	BMS-754807	0.1226
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	Linsitinib	1.8852
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	GSK1904529A	7.4587
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	BMS-536924	5.2043
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	BMS-536924	5.8179
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	GSK1904529A	21.883
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	Linsitinib	40.694
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	NVP-ADW742	11.596
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	BMS-754807	1.0155
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	BMS-754807	0.4783
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	Linsitinib	11.8142
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	GSK1904529A	12.4574
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	BMS-536924	0.7393
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	BMS-536924	0.5696
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	GSK1904529A	342.82
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	Linsitinib	2.6963
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	NVP-ADW742	1.8121
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	BMS-754807	0.0528
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	BMS-536924	9.0589
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	BMS-754807	0.7653
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	Linsitinib	2.7472
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	GSK1904529A	9.1054
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	BMS-536924	1.1087
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	BMS-536924	5.9473
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	GSK1904529A	55.744
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	Linsitinib	8.8272
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	NVP-ADW742	3.8583
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	BMS-536924	9.0589
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	BMS-754807	0.7653
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	Linsitinib	2.7472
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	GSK1904529A	9.1054
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	BMS-536924	1.1087
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	BMS-536924	5.9473
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	GSK1904529A	55.744
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	Linsitinib	8.8272
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	NVP-ADW742	3.8583
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	BMS-754807	2.5279
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	Linsitinib	34.4248
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	GSK1904529A	6.3395
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	BMS-536924	5.1217
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	GSK1904529A	61.114
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	Linsitinib	76.594
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	BMS-754807	1.9847
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	Linsitinib	6.0608
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	GSK1904529A	13.5024
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	BMS-536924	1.3757
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	BMS-536924	18.627
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	GSK1904529A	113.54
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	Linsitinib	112.28
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	NVP-ADW742	252.29
SIDM00193	COREAD\|large_intestine	p.F777L (No)	GDSC	BMS-536924	51.2628
SIDM00193	COREAD\|large_intestine	p.F777L (No)	GDSC	GSK1904529A	120.43
SIDM00193	COREAD\|large_intestine	p.F777L (No)	GDSC	Linsitinib	84.967
SIDM00193	COREAD\|large_intestine	p.F777L (No)	GDSC	BMS-754807	31.752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JLT2	Mediator of RNA polymerase II transcription subunit 19	DEG_SPOP_SBC_1	237:241	ASSSS	SPOP	0.692	More...
A2VDJ0	Transmembrane protein 131-like	DEG_SPOP_SBC_1	909:913	ASSSS	SPOP	0.7658	More...
A4D161	Protein FAM221A	DEG_SPOP_SBC_1	237:241	ASSSS	SPOP	0.9261	More...
O00571	ATP-dependent RNA helicase DDX3X	DEG_SPOP_SBC_1	608:612	ASSSS	SPOP	0.9984	More...
O14492	SH2B adapter protein 2	DEG_SPOP_SBC_1	566:570	ASSSS	SPOP	0.9979	More...
O14492	SH2B adapter protein 2	DEG_SPOP_SBC_1	571:575	ASSSS	SPOP	0.9977	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	259:263	ASSSS	SPOP	0.8451	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2168:2172	ASSSS	SPOP	0.9964	More...
O15047	Histone-lysine N-methyltransferase SETD1A	DEG_SPOP_SBC_1	339:343	ASSSS	SPOP	0.9582	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	865:869	ASSSS	SPOP	0.9886	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	214:218	ASSSS	SPOP	0.9963	More...
O15534	Period circadian protein homolog 1	DEG_SPOP_SBC_1	652:656	ASSSS	SPOP	0.9988	More...
O43189	PHD finger protein 1	DEG_SPOP_SBC_1	495:499	ASSSS	SPOP	0.9504	More...
O43474	Krueppel-like factor 4	DEG_SPOP_SBC_1	130:134	ASSSS	SPOP	0.7205	More...
O75197	Low-density lipoprotein receptor-related protein 5	DEG_SPOP_SBC_1	1481:1485	ASSSS	SPOP	0.9948	More...
O75581	Low-density lipoprotein receptor-related protein 6	DEG_SPOP_SBC_1	1468:1472	ASSSS	SPOP	0.9959	More...
P08047	Transcription factor Sp1	DEG_SPOP_SBC_1	315:319	ASSSS	SPOP	0.8981	More...
P08069	Insulin-like growth factor 1 receptor	DEG_SPOP_SBC_1	1309:1313	ASSSS	SPOP	0.9782	More...
P11308	Transcriptional regulator ERG	DEG_SPOP_SBC_1	35:39	ASSSS	SPOP	0.992	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	776:780	ASSSS	SPOP	0.9929	More...
P31249	Homeobox protein Hox-D3	DEG_SPOP_SBC_1	149:153	ASSSS	SPOP	0.9801	More...
P32242	Homeobox protein OTX1	DEG_SPOP_SBC_1	136:140	ASSSS	SPOP	0.9354	More...
P32242	Homeobox protein OTX1	DEG_SPOP_SBC_1	142:146	ASSSS	SPOP	0.9168	More...
P34925	Tyrosine-protein kinase RYK	DEG_SPOP_SBC_1	266:270	ASSSS	SPOP	0.902	More...
P43356	Melanoma-associated antigen 2	DEG_SPOP_SBC_1	39:43	ASSSS	SPOP	0.94	More...
P43365	Melanoma-associated antigen 12	DEG_SPOP_SBC_1	39:43	ASSSS	SPOP	0.7923	More...
P48995	Short transient receptor potential channel 1	DEG_SPOP_SBC_1	14:18	ASSSS	SPOP	0.9293	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	772:776	ASSSS	SPOP	0.808	More...
P50548	ETS domain-containing transcription factor ERF	DEG_SPOP_SBC_1	364:368	ASSSS	SPOP	0.9956	More...
P51617	Interleukin-1 receptor-associated kinase 1	DEG_SPOP_SBC_1	651:655	ASSSS	SPOP	0.9942	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	311:315	ASSSS	SPOP	0.9518	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	278:282	ASSSS	SPOP	0.9963	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	327:331	ASSSS	SPOP	0.9982	More...
P78424	POU domain, class 6, transcription factor 2	DEG_SPOP_SBC_1	447:451	ASSSS	SPOP	0.9845	More...
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SPOP_SBC_1	1037:1041	ASSSS	SPOP	0.9687	More...
Q02388	Collagen alpha-1	DEG_SPOP_SBC_1	697:701	ASSSS	SPOP	0.9041	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	89:93	ASSSS	SPOP	0.9982	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	3335:3339	ASSSS	SPOP	0.7076	More...
Q04727	Transducin-like enhancer protein 4	DEG_SPOP_SBC_1	297:301	ASSSS	SPOP	0.9988	More...
Q08945	FACT complex subunit SSRP1	DEG_SPOP_SBC_1	501:505	ASSSS	SPOP	0.9979	More...
Q08AD1	Calmodulin-regulated spectrin-associated protein 2	DEG_SPOP_SBC_1	689:693	ASSSS	SPOP	0.9974	More...
Q12791	Calcium-activated potassium channel subunit alpha-1	DEG_SPOP_SBC_1	38:42	ASSSS	SPOP	0.9676	More...
Q12888	TP53-binding protein 1	DEG_SPOP_SBC_1	1641:1645	ASSSS	SPOP	0.9831	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_SPOP_SBC_1	1745:1749	ASSSS	SPOP	0.9253	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	57:61	ASSSS	SPOP	0.9363	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	149:153	ASSSS	SPOP	0.9377	More...
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_SPOP_SBC_1	832:836	ASSSS	SPOP	0.9965	More...
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SPOP_SBC_1	1268:1272	ASSSS	SPOP	0.9827	More...
Q16891	MICOS complex subunit MIC60	DEG_SPOP_SBC_1	189:193	ASSSS	SPOP	0.8148	More...
Q2Q1W2	E3 ubiquitin-protein ligase TRIM71	DEG_SPOP_SBC_1	31:35	ASSSS	SPOP	0.8838	More...
Q3L8U1	Chromodomain-helicase-DNA-binding protein 9	DEG_SPOP_SBC_1	2174:2178	ASSSS	SPOP	0.9639	More...
Q569K4	Zinc finger protein 385B	DEG_SPOP_SBC_1	231:235	ASSSS	SPOP	0.8099	More...
Q5JU85	IQ motif and SEC7 domain-containing protein 2	DEG_SPOP_SBC_1	1230:1234	ASSSS	SPOP	0.8255	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	3345:3349	ASSSS	SPOP	0.9691	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	777:781	ASSSS	SPOP	0.9765	More...
Q5TCX8	Mitogen-activated protein kinase kinase kinase 21	DEG_SPOP_SBC_1	25:29	ASSSS	SPOP	0.97	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	1109:1113	ASSSS	SPOP	0.9757	More...
Q5VT06	Centrosome-associated protein 350	DEG_SPOP_SBC_1	708:712	ASSSS	SPOP	0.9973	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	12:16	ASSSS	SPOP	0.9241	More...
Q5VTR2	E3 ubiquitin-protein ligase BRE1A	DEG_SPOP_SBC_1	163:167	ASSSS	SPOP	0.5674	More...
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_SPOP_SBC_1	1440:1444	ASSSS	SPOP	0.8903	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	548:552	ASSSS	SPOP	0.9987	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	607:611	ASSSS	SPOP	0.9585	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1079:1083	ASSSS	SPOP	0.9475	More...
Q6DJT9	Zinc finger protein PLAG1	DEG_SPOP_SBC_1	376:380	ASSSS	SPOP	0.9452	More...
Q6ZN04	RNA-binding protein MEX3B	DEG_SPOP_SBC_1	404:408	ASSSS	SPOP	0.8445	More...
Q6ZUT1	Uncharacterized protein NKAPD1	DEG_SPOP_SBC_1	234:238	ASSSS	SPOP	0.7532	More...
Q7Z3H0	Photoreceptor ankyrin repeat protein	DEG_SPOP_SBC_1	407:411	ASSSS	SPOP	0.9925	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	254:258	ASSSS	SPOP	0.9555	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	1631:1635	ASSSS	SPOP	0.9194	More...
Q8IVL1	Neuron navigator 2	DEG_SPOP_SBC_1	1411:1415	ASSSS	SPOP	0.9427	More...
Q8IVW6	AT-rich interactive domain-containing protein 3B	DEG_SPOP_SBC_1	532:536	ASSSS	SPOP	0.9828	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	233:237	ASSSS	SPOP	0.8805	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	23:27	ASSSS	SPOP	0.9155	More...
Q8IXZ2	Zinc finger CCCH domain-containing protein 3	DEG_SPOP_SBC_1	386:390	ASSSS	SPOP	0.9761	More...
Q8IXZ2	Zinc finger CCCH domain-containing protein 3	DEG_SPOP_SBC_1	872:876	ASSSS	SPOP	0.9634	More...
Q8IY26	Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6	DEG_SPOP_SBC_1	17:21	ASSSS	SPOP	0.9988	More...
Q8N6K0	Testis-expressed protein 29	DEG_SPOP_SBC_1	108:112	ASSSS	SPOP	0.9978	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1891:1895	ASSSS	SPOP	0.9753	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	3245:3249	ASSSS	SPOP	0.9886	More...
Q8WWN9	Interactor protein for cytohesin exchange factors 1	DEG_SPOP_SBC_1	183:187	ASSSS	SPOP	0.996	More...
Q8WWX8	Sodium/myo-inositol cotransporter 2	DEG_SPOP_SBC_1	587:591	ASSSS	SPOP	0.9469	More...
Q8WXH0	Nesprin-2	DEG_SPOP_SBC_1	4155:4159	ASSSS	SPOP	0.9945	More...
Q92734	Protein TFG	DEG_SPOP_SBC_1	211:215	ASSSS	SPOP	0.9523	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	375:379	ASSSS	SPOP	0.9985	More...
Q92800	Histone-lysine N-methyltransferase EZH1	DEG_SPOP_SBC_1	397:401	ASSSS	SPOP	0.9923	More...
Q92833	Protein Jumonji	DEG_SPOP_SBC_1	1235:1239	ASSSS	SPOP	0.9876	More...
Q92833	Protein Jumonji	DEG_SPOP_SBC_1	1242:1246	ASSSS	SPOP	0.8412	More...
Q969Z3	Mitochondrial amidoxime reducing component 2	DEG_SPOP_SBC_1	3:7	ASSSS	SPOP	0.7836	More...
Q96L96	Alpha-protein kinase 3	DEG_SPOP_SBC_1	767:771	ASSSS	SPOP	0.9904	More...
Q96QT6	PHD finger protein 12	DEG_SPOP_SBC_1	928:932	ASSSS	SPOP	0.8699	More...
Q9BZS1	Forkhead box protein P3	DEG_SPOP_SBC_1	56:60	ASSSS	SPOP	0.8871	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	719:723	ASSSS	SPOP	0.867	More...
Q9H7S9	Zinc finger protein 703	DEG_SPOP_SBC_1	211:215	ASSSS	SPOP	0.9972	More...
Q9HCG8	Pre-mRNA-splicing factor CWC22 homolog	DEG_SPOP_SBC_1	674:678	ASSSS	SPOP	0.9842	More...
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	480:484	ASSSS	SPOP	0.9795	More...
Q9NPF5	DNA methyltransferase 1-associated protein 1	DEG_SPOP_SBC_1	455:459	ASSSS	SPOP	0.7946	More...
Q9NPG3	Ubinuclein-1	DEG_SPOP_SBC_1	867:871	ASSSS	SPOP	0.9938	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1544:1548	ASSSS	SPOP	0.9686	More...
Q9NTI5	Sister chromatid cohesion protein PDS5 homolog B	DEG_SPOP_SBC_1	1158:1162	ASSSS	SPOP	0.9447	More...
Q9NY27	Serine/threonine-protein phosphatase 4 regulatory subunit 2	DEG_SPOP_SBC_1	278:282	ASSSS	SPOP	0.9992	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_SPOP_SBC_1	101:105	ASSSS	SPOP	0.9956	More...
Q9P286	Serine/threonine-protein kinase PAK 5	DEG_SPOP_SBC_1	222:226	ASSSS	SPOP	0.7523	More...
Q9UBN1	Voltage-dependent calcium channel gamma-4 subunit	DEG_SPOP_SBC_1	224:228	ASSSS	SPOP	0.7395	More...
Q9UFE4	Coiled-coil domain-containing protein 39	DEG_SPOP_SBC_1	927:931	ASSSS	SPOP	0.9527	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	239:243	ASSSS	SPOP	0.9888	More...
Q9UJ98	Cohesin subunit SA-3	DEG_SPOP_SBC_1	18:22	ASSSS	SPOP	0.9571	More...
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	131:135	ASSSS	SPOP	0.9942	More...
Q9ULI2	Beta-citrylglutamate synthase B	DEG_SPOP_SBC_1	346:350	ASSSS	SPOP	0.9949	More...
Q9UPA5	Protein bassoon	DEG_SPOP_SBC_1	2649:2653	ASSSS	SPOP	0.9177	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	1049:1053	ASSSS	SPOP	0.9758	More...
Q9Y446	Plakophilin-3	DEG_SPOP_SBC_1	219:223	ASSSS	SPOP	0.9994	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	255:259	ASSSS	SPOP	0.9956	More...
Q9Y4C0	Neurexin-3	DEG_SPOP_SBC_1	1486:1490	ASSSS	SPOP	0.9784	More...
Q9Y4X4	Krueppel-like factor 12	DEG_SPOP_SBC_1	136:140	ASSSS	SPOP	0.9685	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	1973:1977	ASSSS	SPOP	0.9913	More...
Q9Y5X1	Sorting nexin-9	DEG_SPOP_SBC_1	196:200	ASSSS	SPOP	0.9833	More...
A1L020	RNA-binding protein MEX3A	DEG_SPOP_SBC_1	408:412	ASSSS	SPOP	0.9395	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_SPOP_SBC_1	1648:1652	ASSSS	SPOP	0.861	More...
Q6T4P5	Phospholipid phosphatase-related protein type 3	DEG_SPOP_SBC_1	557:561	ASSSS	SPOP	0.9987	More...
Q86UZ6	Zinc finger and BTB domain-containing protein 46	DEG_SPOP_SBC_1	148:152	ASSSS	SPOP	0.8507	More...
Q8N143	B-cell CLL/lymphoma 6 member B protein	DEG_SPOP_SBC_1	233:237	ASSSS	SPOP	0.8845	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	733:737	ASSSS	SPOP	0.9903	More...
Q6NT52	Choriogonadotropin subunit beta variant 2	DEG_SPOP_SBC_1	135:139	ASSSS	SPOP	0.9986	More...
Q9P227	Rho GTPase-activating protein 23	DEG_SPOP_SBC_1	1347:1351	ASSSS	SPOP	0.9739	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	392:396	ASSSS	SPOP	0.9991	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	666:670	ASSSS	SPOP	0.9988	More...
O15480	Melanoma-associated antigen B3	DEG_SPOP_SBC_1	340:344	ASSSS	SPOP	0.9907	More...
Q69YW2	Protein stum homolog	DEG_SPOP_SBC_1	25:29	ASSSS	SPOP	0.8246	More...
Q6PEV8	Protein FAM199X	DEG_SPOP_SBC_1	282:286	ASSSS	SPOP	0.9905	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SPOP_SBC_1	4:8	ASSSS	SPOP	0.8704	More...
Q9NQR7	Coiled-coil domain-containing protein 177	DEG_SPOP_SBC_1	250:254	ASSSS	SPOP	0.9585	More...
Q9NUC0	SERTA domain-containing protein 4	DEG_SPOP_SBC_1	222:226	ASSSS	SPOP	0.8625	More...
Q9NX31	Oxidative stress-responsive serine-rich protein 1	DEG_SPOP_SBC_1	99:103	ASSSS	SPOP	0.9942	More...
A8MZG2	Uncharacterized protein C16orf90	DEG_SPOP_SBC_1	134:138	ASSSS	SPOP	0.7432	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSSS

Degron related mutations and impact score

Drug responses associated with IGF1R mutations

All proteins holding degron of ASSSS