DegronMD - Q8IVL1(NAV2)

FUNCTION: Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs. {ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073}.

GO - Biological processes (BP): glossopharyngeal nerve development [GO:0021563]; locomotory behavior [GO:0007626]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; optic nerve development [GO:0021554]; regulation of systemic arterial blood pressure by baroreceptor feedback [GO:0003025]; sensory perception of sme... View more >>

GO - Molecular function (MF): 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; heparin binding [GO:0008201]

GO - Cellular component (CC): interstitial matrix [GO:0005614]; nucleoplasm [GO:0005654]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1675H	ACH-001377	Pancreatic Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	1675:1679	Mutation altering degron motif	0.8244
p.S548N	SIDM00499	Prostate Carcinoma	GDSC	EDPSGAAVPEM	DEG_COP1_1	545:555	Mutation altering degron motif	0.818
p.S548N	22RV1	prostate	COSMIC	EDPSGAAVPEM	DEG_COP1_1	545:555	Mutation altering degron motif	0.818
p.S1413F	DO220907	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	1411:1415	Mutation altering degron motif	0.7982
p.S550F	ACH-001550	Skin Cancer	CCLE	EDPSGAAVPEM	DEG_COP1_1	545:555	Mutation altering degron motif	0.7982
p.S550F	MCC13	skin	COSMIC	EDPSGAAVPEM	DEG_COP1_1	545:555	Mutation altering degron motif	0.7982
p.G716W	DO229022	LICA	ICGC	AESSS	DEG_SPOP_SBC_1	712:716	Mutation altering degron motif	0.7825
p.A479E	KYSE-410	oesophagus	COSMIC	PASSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7701
p.S1679L	TCGA-EO-A22U	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	1675:1679	Mutation altering degron motif	0.7667
p.A712S	TCGA-BR-7704	STAD	TCGA	AESSS	DEG_SPOP_SBC_1	712:716	Mutation altering degron motif	0.7588
p.A479S	DO229022	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7588
p.M1675V	DO218859	SKCA	ICGC	VSSTS	DEG_SPOP_SBC_1	1675:1679	Mutation altering degron motif	0.7208
p.A1411T	TCGA-AJ-A3EK	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1411:1415	Mutation altering degron motif	0.7139
p.A1411T	TCGA-AX-A06F	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1411:1415	Mutation altering degron motif	0.7139
p.A479T	DO42033	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7139
p.P477T	SIDM02050	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7031
p.D1415N	DO42713	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1411:1415	Mutation altering degron motif	0.6932
p.K553N	DO36556	READ	ICGC	EDPSGAAVPEM	DEG_COP1_1	545:555	Mutation altering degron motif	0.6918
p.S480T	DO51537	PACA	ICGC	PASSS	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.6005
p.E554D	TCGA-B5-A3FA	UCEC	TCGA	EDPSGAAVPEM	DEG_COP1_1	545:555	Mutation altering degron motif	0.5647

Showing 1 to 20 of 113 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NAV2

UniProt ID: Q8IVL1

Entrez ID: 89797

Protein name: Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NAV2 in