DegronMD

Uniprot ID: Q8IVL1

Source protein: Neuron navigator 2

Source gene: NAV2

Class: DEG_COP1_1

Location: 545:555

E3 ligase: COP1

DEGRON score: 0.9468

ASA_SCORE: 89.4818

COIL: 0.9286

CONS_SCORE: 0.3187

DSS_SCORE: 0.6662

HELIX: 0.0334

FCONS_SCORE: 0.8901

RIG_SCORE: 0.6273

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S559F	TCGA-AL-3472	KIRP	TCGA	EDPSGAAVPEM	DEG_COP1_1	0.2222
p.S559F	SIDM01090	Colorectal Carcinoma	GDSC	EDPSGAAVPEM	DEG_COP1_1	0.2222
p.S559F	RKO	large_intestine	COSMIC	EDPSGAAVPEM	DEG_COP1_1	0.2222
p.K558Q	TCGA-B5-A0JY	UCEC	TCGA	EDPSGAAVPEM	DEG_COP1_1	0.3611
p.E554D	TCGA-B5-A3FA	UCEC	TCGA	EDPSGAAVPEM	DEG_COP1_1	0.5647
p.K561N	TCGA-BK-A6W3	UCEC	TCGA	EDPSGAAVPEM	DEG_COP1_1	0.2778
p.A558V	DO222440	ESCA	ICGC	EDPSGAAVPEM	DEG_COP1_1	0.3611
p.S536F	DO20923	KIRP	ICGC	EDPSGAAVPEM	DEG_COP1_1	0.0833
p.S536F	RKO	large_intestine	COSMIC	EDPSGAAVPEM	DEG_COP1_1	0.0833
p.K553N	DO36556	READ	ICGC	EDPSGAAVPEM	DEG_COP1_1	0.6918
p.P544S	DO47569	SKCM	ICGC	EDPSGAAVPEM	DEG_COP1_1	0.3056
p.P565L	DO47989	STAD	ICGC	EDPSGAAVPEM	DEG_COP1_1	0.0556
p.K538N	DO50076	UCEC	ICGC	EDPSGAAVPEM	DEG_COP1_1	0.1389
p.K535Q	DO43041	UCEC	ICGC	EDPSGAAVPEM	DEG_COP1_1	0.0556
p.S562C	DO41325	UCEC	ICGC	EDPSGAAVPEM	DEG_COP1_1	0.1389
p.S548N	SIDM00499	Prostate Carcinoma	GDSC	EDPSGAAVPEM	DEG_COP1_1	0.818
p.S548N	22RV1	prostate	COSMIC	EDPSGAAVPEM	DEG_COP1_1	0.818
p.A563S	SIDM00277	Acute Myeloid Leukemia	GDSC	EDPSGAAVPEM	DEG_COP1_1	0.1111
p.A563S	ACH-000198	Leukemia	CCLE	EDPSGAAVPEM	DEG_COP1_1	0.1111
p.A563S	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	EDPSGAAVPEM	DEG_COP1_1	0.1111
p.S550F	ACH-001550	Skin Cancer	CCLE	EDPSGAAVPEM	DEG_COP1_1	0.7982
p.S550F	MCC13	skin	COSMIC	EDPSGAAVPEM	DEG_COP1_1	0.7982
p.S562N	DU-145	prostate	COSMIC	EDPSGAAVPEM	DEG_COP1_1	0.1389
p.A540S	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	EDPSGAAVPEM	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVL1	Neuron navigator 2	DEG_COP1_1	545:555	EDPSGAAVPEM	COP1	0.9468	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons