DegronMD - Q9NPF5(DMAP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R368Q	TCGA-AZ-4315	COAD	TCGA	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.0833
p.R368Q	DO8842	COAD	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.0833
p.L346V	TCGA-BG-A0M6	UCEC	TCGA	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.1667
p.L346V	DO40863	UCEC	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.1667
p.T357M	TCGA-BR-8591	STAD	TCGA	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.7423
p.T357M	DO47973	STAD	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.7423
p.N447S	TCGA-EO-A22S	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1111
p.N447S	DO41590	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1111
p.P356T	DO887	BOCA	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.7031
p.T355I	DO229016	COCA	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation altering degron motif	0.8189
p.G349C	DO229015	LICA	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.25
p.K466N	DO229035	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	455:459	Mutation substituting flanking lysine	0.25
p.R452W	SIDM01169	Ovarian Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.25
p.R452W	ACH-000885	Ovarian Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.25
p.R452W	TOV-21G	ovary	COSMIC	ASSSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.25
p.S369R	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.0556
p.S369R	ACH-000451	Lung Cancer	CCLE	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.0556
p.S369R	NCI-H2085	lung	COSMIC	LSPTPTEE	DEG_SCF_FBW7_2	352:359	Mutation rewiring degron network	0.0556

Kaplan plot for DMAP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMAP1

UniProt ID: Q9NPF5

Entrez ID: 55929

Protein name: DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMAP1 in