DegronMD

Uniprot ID: Q9NPF5

Source protein: DNA methyltransferase 1-associated protein 1

Source gene: DMAP1

Class: DEG_SCF_FBW7_2

Location: 352:359

E3 ligase: FBXW7

DEGRON score: 0.8081

ASA_SCORE: 69.8

COIL: 0.7104

CONS_SCORE: 0.4321

DSS_SCORE: 0.2127

HELIX: 0.2683

FCONS_SCORE: 1.0477

RIG_SCORE: 0.7489

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R368Q	TCGA-AZ-4315	COAD	TCGA	LSPTPTEE	DEG_SCF_FBW7_2	0.0833
p.R368Q	DO8842	COAD	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	0.0833
p.L346V	TCGA-BG-A0M6	UCEC	TCGA	LSPTPTEE	DEG_SCF_FBW7_2	0.1667
p.L346V	DO40863	UCEC	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	0.1667
p.T357M	TCGA-BR-8591	STAD	TCGA	LSPTPTEE	DEG_SCF_FBW7_2	0.7423
p.T357M	DO47973	STAD	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	0.7423
p.P356T	DO887	BOCA	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	0.7031
p.T355I	DO229016	COCA	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	0.8189
p.G349C	DO229015	LICA	ICGC	LSPTPTEE	DEG_SCF_FBW7_2	0.25
p.S369R	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	LSPTPTEE	DEG_SCF_FBW7_2	0.0556
p.S369R	ACH-000451	Lung Cancer	CCLE	LSPTPTEE	DEG_SCF_FBW7_2	0.0556
p.S369R	NCI-H2085	lung	COSMIC	LSPTPTEE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPF5	DNA methyltransferase 1-associated protein 1	DEG_SCF_FBW7_2	352:359	LSPTPTEE	FBXW7	0.8081	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons