DegronMD - Q6ZN04(MEX3B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F281L	TCGA-55-7994	LUAD	TCGA	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation rewiring degron network	0.1111
p.F281L	DO45311	LUAD	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation rewiring degron network	0.1111
p.S402L	TCGA-63-A5ML	LUSC	TCGA	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1389
p.S402L	TCGA-63-A5ML	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.2778
p.S402L	DO219151	LUSC	ICGC	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1389
p.S402L	DO219151	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.2778
p.S282C	TCGA-69-7978	LUAD	TCGA	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation rewiring degron network	0.0833
p.S282C	DO24920	LUAD	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation rewiring degron network	0.0833
p.S402P	TCGA-AB-2849	LAML	TCGA	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1389
p.S402P	TCGA-AB-2849	LAML	TCGA	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.2778
p.S402P	DO21403	LAML	ICGC	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1389
p.S402P	DO21403	LAML	ICGC	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.2778
p.S394Y	TCGA-AN-A046	BRCA	TCGA	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.712
p.S394Y	DO1285	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.712
p.S394Y	SIDM00781	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.712
p.S394Y	SIDM00780	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.712
p.S394Y	SIDM01574	Plasma Cell Myeloma	GDSC	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.712
p.S394Y	ACH-000588	Myeloma	CCLE	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.712
p.S394Y	ACH-000967	Colon/Colorectal Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.712
p.S394Y	ACH-001199	Colon/Colorectal Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.712
p.S394Y	SNU-C2B	large intestine	COSMIC	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.712
p.P270H	TCGA-D3-A3C6	SKCM	TCGA	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.7694
p.P270H	DO37507	SKCM	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.7694
p.V409M	TCGA-DF-A2KR	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.3056
p.V409M	DO223284	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.3056
p.V409M	DO42673	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.3056
p.V392I	TCGA-HU-A4H3	STAD	TCGA	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.5965
p.V392I	DO47903	STAD	ICGC	PVSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.5965
p.T269P	DO222732	BTCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.7031
p.T269P	DO229044	LICA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.7031
p.T269P	DO232751	PBCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.7031
p.T269P	DO232811	PBCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.7031
p.T269P	DO229133	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.7031
p.T269P	DO229163	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.7031
p.T269P	DO229191	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.7031
p.T269P	DO229089	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.7031
p.T269P	DO229088	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.7031
p.G277S	DO227802	COCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation rewiring degron network	0.2222
p.A416T	DO227987	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.1111
p.T275N	DO229015	LICA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation rewiring degron network	0.2778
p.T275N	ACH-001201	Brain Cancer	CCLE	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation rewiring degron network	0.2778
p.S407F	DO220851	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.7982
p.S407F	DO222843	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.7982
p.S407F	SIDM01128	Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.7982
p.S407F	ACH-000767	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.7982
p.S407F	NCI-H526	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation altering degron motif	0.7982
p.P412L	DO229446	SKCA	ICGC	ASSSS	DEG_SPOP_SBC_1	404:408	Mutation rewiring degron network	0.2222
p.S271R	DO229510	SKCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.6316
p.S271R	DO229133	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.6316
p.S271R	DO229144	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.6316
p.S271R	DO229191	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.6316
p.S271R	DO229195	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.6316
p.S271R	DO229089	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.6316
p.K279R	SIDM01450	Gastric Carcinoma	GDSC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation substituting flanking lysine	0.2778
p.K279R	ACH-000898	Gastric Cancer	CCLE	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation substituting flanking lysine	0.2778
p.P268L	SIDM01690	Plasma Cell Myeloma	GDSC	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.6471
p.P268L	ACH-000453	Myeloma	CCLE	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation altering degron motif	0.6471
p.T275P	ACH-000136	Neuroblastoma	CCLE	PTPSIT	DEG_SCF_FBW7_1	268:273	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEX3B

UniProt ID: Q6ZN04

Entrez ID: 84206

Protein name: RNA-binding protein MEX3B (RING finger and KH domain-containing protein 3) (RING finger protein 195)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEX3B in