DegronMD

Uniprot ID: Q6ZN04

Source protein: RNA-binding protein MEX3B

Source gene: MEX3B

Class: DEG_SCF_FBW7_1

Location: 268:273

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 79.0167

COIL: 0.9672

CONS_SCORE: 0.4473

DSS_SCORE: 0.655

HELIX: 0.0103

FCONS_SCORE: 0.8928

RIG_SCORE: 0.6445

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F281L	TCGA-55-7994	LUAD	TCGA	PTPSIT	DEG_SCF_FBW7_1	0.1111
p.F281L	DO45311	LUAD	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.1111
p.S282C	TCGA-69-7978	LUAD	TCGA	PTPSIT	DEG_SCF_FBW7_1	0.0833
p.S282C	DO24920	LUAD	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.0833
p.P270H	TCGA-D3-A3C6	SKCM	TCGA	PTPSIT	DEG_SCF_FBW7_1	0.7694
p.P270H	DO37507	SKCM	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.7694
p.T269P	DO222732	BTCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.7031
p.T269P	DO229044	LICA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.7031
p.T269P	DO232751	PBCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.7031
p.T269P	DO232811	PBCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.7031
p.T269P	DO229133	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.7031
p.T269P	DO229163	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.7031
p.T269P	DO229191	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.7031
p.T269P	DO229089	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.7031
p.T269P	DO229088	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.7031
p.G277S	DO227802	COCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.2222
p.T275N	DO229015	LICA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.2778
p.T275N	ACH-001201	Brain Cancer	CCLE	PTPSIT	DEG_SCF_FBW7_1	0.2778
p.S271R	DO229510	SKCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.6316
p.S271R	DO229133	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.6316
p.S271R	DO229144	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.6316
p.S271R	DO229191	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.6316
p.S271R	DO229195	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.6316
p.S271R	DO229089	THCA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.6316
p.K279R	SIDM01450	Gastric Carcinoma	GDSC	PTPSIT	DEG_SCF_FBW7_1	0.2778
p.K279R	ACH-000898	Gastric Cancer	CCLE	PTPSIT	DEG_SCF_FBW7_1	0.2778
p.P268L	SIDM01690	Plasma Cell Myeloma	GDSC	PTPSIT	DEG_SCF_FBW7_1	0.6471
p.P268L	ACH-000453	Myeloma	CCLE	PTPSIT	DEG_SCF_FBW7_1	0.6471
p.T275P	ACH-000136	Neuroblastoma	CCLE	PTPSIT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZN04	RNA-binding protein MEX3B	DEG_SCF_FBW7_1	268:273	PTPSIT	FBXW7	0.9969	More...
A8MWE9	EF-hand calcium-binding domain-containing protein 8	DEG_SCF_FBW7_1	30:35	PTPSIT	FBXW7	0.9441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPSIT

Degron related mutations and impact score

Drug responses associated with MEX3B mutations

All proteins holding degron of PTPSIT