DegronMD

Uniprot ID: A8MWE9

Source protein: EF-hand calcium-binding domain-containing protein 8

Source gene: EFCAB8

Class: DEG_SCF_FBW7_1

Location: 30:35

E3 ligase: FBXW7

DEGRON score: 0.9441

ASA_SCORE: 82.4

COIL: 0.9317

CONS_SCORE: 0.1625

DSS_SCORE: 0.5842

HELIX: 0.0268

FCONS_SCORE: 0.9696

RIG_SCORE: 0.6479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R43M	DO233652	GACA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.1111
p.S28I	DO228952	LICA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.2778
p.P29S	DO222402	MELA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.3056
p.S29F	DO222710	MELA	ICGC	PTPSIT	DEG_SCF_FBW7_1	0.3056
p.S29F	ACH-001566	Skin Cancer	CCLE	PTPSIT	DEG_SCF_FBW7_1	0.3056
p.I34T	SIDM00517	Head and Neck Carcinoma	GDSC	PTPSIT	DEG_SCF_FBW7_1	0.5966
p.I34T	ACH-002239	Head and Neck Cancer	CCLE	PTPSIT	DEG_SCF_FBW7_1	0.5966
p.I34T	H3118	upper_aerodigestive_tract	COSMIC	PTPSIT	DEG_SCF_FBW7_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZN04	RNA-binding protein MEX3B	DEG_SCF_FBW7_1	268:273	PTPSIT	FBXW7	0.9969	More...
A8MWE9	EF-hand calcium-binding domain-containing protein 8	DEG_SCF_FBW7_1	30:35	PTPSIT	FBXW7	0.9441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons