DegronMD - A8MWE9(EFCAB8)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R43M	DO233652	GACA	ICGC	SITLSQVPDL	DEG_COP1_1	33:42	Mutation rewiring degron network	0.3056
p.R43M	DO233652	GACA	ICGC	PTPSIT	DEG_SCF_FBW7_1	30:35	Mutation rewiring degron network	0.1111
p.S28I	DO228952	LICA	ICGC	SITLSQVPDL	DEG_COP1_1	33:42	Mutation rewiring degron network	0.1944
p.S28I	DO228952	LICA	ICGC	PTPSIT	DEG_SCF_FBW7_1	30:35	Mutation rewiring degron network	0.2778
p.P29S	DO222402	MELA	ICGC	SITLSQVPDL	DEG_COP1_1	33:42	Mutation rewiring degron network	0.2222
p.P29S	DO222402	MELA	ICGC	PTPSIT	DEG_SCF_FBW7_1	30:35	Mutation rewiring degron network	0.3056
p.S29F	DO222710	MELA	ICGC	SITLSQVPDL	DEG_COP1_1	33:42	Mutation rewiring degron network	0.2222
p.S29F	DO222710	MELA	ICGC	PTPSIT	DEG_SCF_FBW7_1	30:35	Mutation rewiring degron network	0.3056
p.S29F	ACH-001566	Skin Cancer	CCLE	SITLSQVPDL	DEG_COP1_1	33:42	Mutation rewiring degron network	0.2222
p.S29F	ACH-001566	Skin Cancer	CCLE	PTPSIT	DEG_SCF_FBW7_1	30:35	Mutation rewiring degron network	0.3056
p.I34T	SIDM00517	Head and Neck Carcinoma	GDSC	SITLSQVPDL	DEG_COP1_1	33:42	Mutation altering degron motif	0.5966
p.I34T	SIDM00517	Head and Neck Carcinoma	GDSC	PTPSIT	DEG_SCF_FBW7_1	30:35	Mutation altering degron motif	0.5966
p.I34T	ACH-002239	Head and Neck Cancer	CCLE	SITLSQVPDL	DEG_COP1_1	33:42	Mutation altering degron motif	0.5966
p.I34T	ACH-002239	Head and Neck Cancer	CCLE	PTPSIT	DEG_SCF_FBW7_1	30:35	Mutation altering degron motif	0.5966
p.I34T	H3118	upper aerodigestive tract	COSMIC	SITLSQVPDL	DEG_COP1_1	33:42	Mutation altering degron motif	0.5966
p.I34T	H3118	upper aerodigestive tract	COSMIC	PTPSIT	DEG_SCF_FBW7_1	30:35	Mutation altering degron motif	0.5966

Kaplan plot for EFCAB8 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFCAB8

UniProt ID: A8MWE9

Entrez ID:

Protein name: EF-hand calcium-binding domain-containing protein 8

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for EFCAB8 in