DegronMD

Uniprot ID: A8MWE9

Source protein: EF-hand calcium-binding domain-containing protein 8

Source gene: EFCAB8

Class: DEG_COP1_1

Location: 33:42

E3 ligase: COP1

DEGRON score: 0.9419

ASA_SCORE: 79.66

COIL: 0.7945

CONS_SCORE: 0.1585

DSS_SCORE: 0.5565

HELIX: 0.166

FCONS_SCORE: 0.7513

RIG_SCORE: 0.709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R43M	DO233652	GACA	ICGC	SITLSQVPDL	DEG_COP1_1	0.3056
p.S28I	DO228952	LICA	ICGC	SITLSQVPDL	DEG_COP1_1	0.1944
p.P29S	DO222402	MELA	ICGC	SITLSQVPDL	DEG_COP1_1	0.2222
p.S29F	DO222710	MELA	ICGC	SITLSQVPDL	DEG_COP1_1	0.2222
p.S29F	ACH-001566	Skin Cancer	CCLE	SITLSQVPDL	DEG_COP1_1	0.2222
p.I34T	SIDM00517	Head and Neck Carcinoma	GDSC	SITLSQVPDL	DEG_COP1_1	0.5966
p.I34T	ACH-002239	Head and Neck Cancer	CCLE	SITLSQVPDL	DEG_COP1_1	0.5966
p.I34T	H3118	upper_aerodigestive_tract	COSMIC	SITLSQVPDL	DEG_COP1_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MWE9	EF-hand calcium-binding domain-containing protein 8	DEG_COP1_1	33:42	SITLSQVPDL	COP1	0.9419	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons