DegronMD - P51617(IRAK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S376R	TCGA-21-1083	LUSC	TCGA	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation blocking phosphorylation signal	0.5556
p.P148L	TCGA-23-2649	OV	TCGA	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation rewiring degron network	0.1667
p.I661T	TCGA-33-6738	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.1667
p.I660T	TCGA-91-6848	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.1944
p.P169A	TCGA-A6-2683	COAD	TCGA	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation rewiring degron network	0.1944
p.P169A	TCGA-A6-2683	COAD	TCGA	APSST	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.1667
p.A646T	TCGA-AA-3663	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.1944
p.P664L	TCGA-AP-A1DK	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.0833
p.P658L	TCGA-B5-A11G	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.25
p.P658L	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.25
p.P658L	NCI-H1155	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.25
p.S654L	TCGA-BK-A6W3	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation altering degron motif	0.7667
p.L388M	TCGA-BS-A0V8	UCEC	TCGA	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.711
p.I662V	TCGA-C8-A1HM	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.1389
p.I662V	TCGA-DD-A3A7	LIHC	TCGA	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.1389
p.T381S	TCGA-CK-4947	COAD	TCGA	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation blocking phosphorylation signal	0.6944
p.V187M	TCGA-DD-A3A9	LIHC	TCGA	APSST	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.1111
p.E656D	TCGA-DF-A2KN	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.3056
p.P657S	TCGA-F1-6874	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.2778
p.L391V	TCGA-L5-A4OW	ESCA	TCGA	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.5654
p.S653L	TCGA-SJ-A6ZI	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation altering degron motif	0.8778
p.P156R	TCGA-ZF-A9RL	BLCA	TCGA	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation altering degron motif	0.6401
p.P182R	DO219078	BLCA	ICGC	APSST	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.25
p.D375Y	DO227942	BRCA	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation blocking phosphorylation signal	0.5278
p.I658V	DO3904	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.25
p.I658V	DO44982	LIHC	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.25
p.A642T	DO9346	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.0833
p.R662L	DO231939	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.1389
p.K381N	DO228957	LICA	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation blocking phosphorylation signal	0.6944
p.A172D	DO229041	LICA	ICGC	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation rewiring degron network	0.1111
p.A172D	DO229041	LICA	ICGC	APSST	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.25
p.S399R	DO219517	LIHC	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation rewiring degron network	0.1389
p.G395V	DO231641	LINC	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation rewiring degron network	0.25
p.I656T	DO23846	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.3056
p.E152D	DO45346	LUAD	ICGC	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation rewiring degron network	0.2778
p.I657T	DO26516	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.2778
p.S402R	DO26769	LUSC	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation rewiring degron network	0.0556
p.G386C	DO220886	MELA	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.6489
p.P174L	DO31779	OV	ICGC	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation rewiring degron network	0.0556
p.P174L	DO31779	OV	ICGC	APSST	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.3056
p.S650L	DO33168	PACA	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation blocking phosphorylation signal	0.75
p.S650L	DO50076	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation blocking phosphorylation signal	0.75
p.R662Q	DO36249	PRAD	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.1389
p.P162Q	DO37866	SKCM	ICGC	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation altering degron motif	0.7035
p.R159L	DO50279	SKCM	ICGC	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation altering degron motif	0.8428
p.P653S	DO38201	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation altering degron motif	0.6752
p.S649L	DO219784	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.2778
p.P660L	DO42033	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.1944
p.P654L	DO43514	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation altering degron motif	0.7582
p.P654L	NCI-H1155	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation altering degron motif	0.7582
p.E652D	DO223282	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation altering degron motif	0.6758
p.A651V	SIDM01183	Other Solid Cancers	GDSC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation altering degron motif	0.5825
p.A651V	UMC-11	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation altering degron motif	0.5825
p.T152S	SIDM00426	Rhabdomyosarcoma	GDSC	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation rewiring degron network	0.2778
p.T152S	ACH-000100	Sarcoma	CCLE	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation rewiring degron network	0.2778
p.T152S	ACH-001765	Sarcoma	CCLE	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation rewiring degron network	0.2778
p.T152S	RH-41	soft tissue	COSMIC	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation rewiring degron network	0.2778
p.V642M	SIDM00212	Glioblastoma	GDSC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.0833
p.V642M	SIDM00932	Kidney Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.0833
p.P162S	SIDM01186	Breast Carcinoma	GDSC	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation altering degron motif	0.6752
p.P162S	ACH-000554	Breast Cancer	CCLE	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation altering degron motif	0.6752
p.P162S	UACC-893	breast	COSMIC	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation altering degron motif	0.6752
p.E393K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation rewiring degron network	0.3056
p.E393K	ACH-000916	Lung Cancer	CCLE	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation rewiring degron network	0.3056
p.E393K	NCI-H1573	lung	COSMIC	VRGTLAYLP	DEG_APCC_DBOX_1	384:392	Mutation rewiring degron network	0.3056
p.T178S	RH-41	soft tissue	COSMIC	APSST	DEG_SPOP_SBC_1	175:179	Mutation altering degron motif	0.7116
p.A151T	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	SGPELGLVPSP	DEG_COP1_1	154:164	Mutation rewiring degron network	0.25
p.A647V	UMC-11	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.2222
p.V642A	HCC2998	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.0833
p.S660G	NCI-H2009	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	651:655	Mutation rewiring degron network	0.1944
p.P188S	UACC-893	breast	COSMIC	APSST	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.0833

Kaplan plot for IRAK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRAK1

UniProt ID: P51617

Entrez ID: 3654

Protein name: Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRAK1 in