DegronMD

Uniprot ID: P51617

Source protein: Interleukin-1 receptor-associated kinase 1

Source gene: IRAK1

Class: DEG_SPOP_SBC_1

Location: 175:179

E3 ligase: SPOP

DEGRON score: 0.9726

ASA_SCORE: 82.86

COIL: 0.9486

CONS_SCORE: 0.3402

DSS_SCORE: 0.6822

HELIX: 0.0272

FCONS_SCORE: 1.0712

RIG_SCORE: 0.4968

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P169A	TCGA-A6-2683	COAD	TCGA	APSST	DEG_SPOP_SBC_1	0.1667
p.V187M	TCGA-DD-A3A9	LIHC	TCGA	APSST	DEG_SPOP_SBC_1	0.1111
p.P182R	DO219078	BLCA	ICGC	APSST	DEG_SPOP_SBC_1	0.25
p.A172D	DO229041	LICA	ICGC	APSST	DEG_SPOP_SBC_1	0.25
p.P174L	DO31779	OV	ICGC	APSST	DEG_SPOP_SBC_1	0.3056
p.T178S	RH-41	soft_tissue	COSMIC	APSST	DEG_SPOP_SBC_1	0.7116
p.P188S	UACC-893	breast	COSMIC	APSST	DEG_SPOP_SBC_1	0.0833

Drug responses associated with IRAK1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.E393K (No)	GDSC	WZ3105	16.7536
SIDM00095	GBM\|glioma	p.R366C (No)	GDSC	WZ3105	0.6666
SIDM00932	KIRC\|kidney	p.V642M (No)	GDSC	WZ3105	4.9105
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P658L (No)	GDSC	WZ3105	24.2807
SIDM00212	GBM\|glioma	p.V642M (No)	GDSC	WZ3105	0.9105
SIDM01090	COREAD\|large_intestine	p.C203S (No)	GDSC	WZ3105	0.2097
SIDM00529	BRCA\|breast	p.P173L (Yes)	GDSC	WZ3105	0.5606
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.S690G (No)	GDSC	WZ3105	25.4931
SIDM01186	BRCA\|breast	p.P162S (No)	GDSC	WZ3105	0.4924
SIDM00530	ESCA\|oesophagus	p.V586M (No)	GDSC	WZ3105	0.5288
SIDM00217	COREAD\|large_intestine	p.L437P (No)	GDSC	WZ3105	0.1618
SIDM00807	BLCA\|bladder	p.P173L (Yes)	GDSC	WZ3105	0.2911
SIDM00396	LAML\|acute_myeloid_leukaemia	p.R366C (No)	GDSC	WZ3105	0.0764
SIDM00274	STAD\|stomach	p.E516K (No)	GDSC	WZ3105	18.5283
SIDM00426	UNCLASSIFIED\|rhabdomyosarcoma	p.T152S (No)	GDSC	WZ3105	0.5116
SIDM00567	MB\|medulloblastoma	p.V188F (Yes)	GDSC	WZ3105	0.118
SIDM01140	UNCLASSIFIED\|ovary	p.P173L (Yes)	GDSC	WZ3105	0.213
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R69fs*6 (No)	GDSC	WZ3105	1.6705
SIDM01183	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A651V (No)	GDSC	WZ3105	0.7103
SIDM00128	HNSC\|head_and_neck	p.G530R (No)	GDSC	WZ3105	0.3456
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.L493_G494delLG (No)	GDSC	WZ3105	0.1956
SIDM00382	GBM\|glioma	p.P218fs*68 (No)	GDSC	WZ3105	27.5385
SIDM00555	GBM\|glioma	p.V586M (No)	GDSC	WZ3105	0.1686
SIDM00092	OV\|ovary	p.S607R (No)	GDSC	WZ3105	1.9954
SIDM00048	LUAD\|lung_NSCLC_adenocarcinoma	p.R194H (No)	GDSC	WZ3105	0.4596
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.R187Q (Yes)	GDSC	WZ3105	0.262
SIDM00579	NB\|neuroblastoma	p.D169G (Yes)	GDSC	WZ3105	18.1424
SIDM00118	COREAD\|large_intestine	p.V642A (No)	GDSC	WZ3105	0.4527

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00468	Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment	DEG_SPOP_SBC_1	1007:1011	APSST	SPOP	0.8779	More...
O14745	Na	DEG_SPOP_SBC_1	310:314	APSST	SPOP	0.9989	More...
O95071	E3 ubiquitin-protein ligase UBR5	DEG_SPOP_SBC_1	1730:1734	APSST	SPOP	0.9784	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	246:250	APSST	SPOP	0.7114	More...
P35637	RNA-binding protein FUS	DEG_SPOP_SBC_1	105:109	APSST	SPOP	0.9597	More...
P46379	Large proline-rich protein BAG6	DEG_SPOP_SBC_1	414:418	APSST	SPOP	0.8466	More...
P48378	DNA-binding protein RFX2	DEG_SPOP_SBC_1	101:105	APSST	SPOP	0.9989	More...
P51617	Interleukin-1 receptor-associated kinase 1	DEG_SPOP_SBC_1	175:179	APSST	SPOP	0.9726	More...
P80723	Brain acid soluble protein 1	DEG_SPOP_SBC_1	192:196	APSST	SPOP	0.9979	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1508:1512	APSST	SPOP	0.9994	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1881:1885	APSST	SPOP	0.9979	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	3235:3239	APSST	SPOP	0.9704	More...
Q14244	Ensconsin	DEG_SPOP_SBC_1	456:460	APSST	SPOP	0.9245	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1031:1035	APSST	SPOP	0.9833	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1633:1637	APSST	SPOP	0.9841	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1656:1660	APSST	SPOP	0.8455	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	2880:2884	APSST	SPOP	0.9592	More...
Q8N183	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2	DEG_SPOP_SBC_1	146:150	APSST	SPOP	0.9957	More...
Q8NC01	C-type lectin domain family 1 member A	DEG_SPOP_SBC_1	42:46	APSST	SPOP	0.6529	More...
Q8NCD3	Holliday junction recognition protein	DEG_SPOP_SBC_1	658:662	APSST	SPOP	0.994	More...
Q96AY4	Tetratricopeptide repeat protein 28	DEG_SPOP_SBC_1	2199:2203	APSST	SPOP	0.9683	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	82:86	APSST	SPOP	0.9637	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2382:2386	APSST	SPOP	0.9772	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1137:1141	APSST	SPOP	0.855	More...
Q9P2K3	REST corepressor 3	DEG_SPOP_SBC_1	397:401	APSST	SPOP	0.8981	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	950:954	APSST	SPOP	0.9976	More...
O75956	Cyclin-dependent kinase 2-associated protein 2	DEG_SPOP_SBC_1	9:13	APSST	SPOP	0.9992	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	458:462	APSST	SPOP	0.708	More...
Q9HCE3	Zinc finger protein 532	DEG_SPOP_SBC_1	730:734	APSST	SPOP	0.9471	More...
A6NHS7	MANSC domain-containing protein 4	DEG_SPOP_SBC_1	173:177	APSST	SPOP	0.9451	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	334:338	APSST	SPOP	0.9671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSST

Degron related mutations and impact score

Drug responses associated with IRAK1 mutations

All proteins holding degron of APSST