DegronMD

Uniprot ID: O00468

Source protein: Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

Source gene: AGRN

Class: DEG_SPOP_SBC_1

Location: 1007:1011

E3 ligase: SPOP

DEGRON score: 0.8779

ASA_SCORE: 61.02

COIL: 0.8294

CONS_SCORE: 0.2514

DSS_SCORE: 0.7208

HELIX: 0.0472

FCONS_SCORE: 1.0035

RIG_SCORE: 0.5665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1019S	TCGA-35-4122	LUAD	TCGA	APSST	DEG_SPOP_SBC_1	0.1111
p.P1019S	DO23782	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	0.1111
p.P1019Q	TCGA-BJ-A28R	THCA	TCGA	APSST	DEG_SPOP_SBC_1	0.1111
p.P1019Q	DO39026	THCA	ICGC	APSST	DEG_SPOP_SBC_1	0.1111
p.P1019L	TCGA-DF-A2KU	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	0.1111
p.P1019L	DO223286	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	0.1111
p.A1012T	DO217788	BRCA	ICGC	APSST	DEG_SPOP_SBC_1	0.3056
p.Q1015P	DO232852	NACA	ICGC	APSST	DEG_SPOP_SBC_1	0.2222
p.T1016N	DO232761	PBCA	ICGC	APSST	DEG_SPOP_SBC_1	0.1944
p.S1009N	DO229221	THCA	ICGC	APSST	DEG_SPOP_SBC_1	0.7069
p.G1002R	DO229232	THCA	ICGC	APSST	DEG_SPOP_SBC_1	0.1944
p.G1002R	ACH-001345	Colon/Colorectal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	0.1944
p.P1008L	SIDM00007	Other Solid Cancers	GDSC	APSST	DEG_SPOP_SBC_1	0.6471
p.P1008L	ACH-001550	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	0.6471
p.P1008L	MCC13	skin	COSMIC	APSST	DEG_SPOP_SBC_1	0.6471
p.P998L	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	0.0833
p.P998L	TE-15	oesophagus	COSMIC	APSST	DEG_SPOP_SBC_1	0.0833
p.P998L	TE-10	oesophagus	COSMIC	APSST	DEG_SPOP_SBC_1	0.0833
p.H1013Q	ACH-002278	Neuroblastoma	CCLE	APSST	DEG_SPOP_SBC_1	0.2778
p.M1016V	C-4-I	cervix	COSMIC	APSST	DEG_SPOP_SBC_1	0.1944
p.T1013M	SNU-1040	large_intestine	COSMIC	APSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00468	Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment	DEG_SPOP_SBC_1	1007:1011	APSST	SPOP	0.8779	More...
O14745	Na	DEG_SPOP_SBC_1	310:314	APSST	SPOP	0.9989	More...
O95071	E3 ubiquitin-protein ligase UBR5	DEG_SPOP_SBC_1	1730:1734	APSST	SPOP	0.9784	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	246:250	APSST	SPOP	0.7114	More...
P35637	RNA-binding protein FUS	DEG_SPOP_SBC_1	105:109	APSST	SPOP	0.9597	More...
P46379	Large proline-rich protein BAG6	DEG_SPOP_SBC_1	414:418	APSST	SPOP	0.8466	More...
P48378	DNA-binding protein RFX2	DEG_SPOP_SBC_1	101:105	APSST	SPOP	0.9989	More...
P51617	Interleukin-1 receptor-associated kinase 1	DEG_SPOP_SBC_1	175:179	APSST	SPOP	0.9726	More...
P80723	Brain acid soluble protein 1	DEG_SPOP_SBC_1	192:196	APSST	SPOP	0.9979	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1508:1512	APSST	SPOP	0.9994	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1881:1885	APSST	SPOP	0.9979	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	3235:3239	APSST	SPOP	0.9704	More...
Q14244	Ensconsin	DEG_SPOP_SBC_1	456:460	APSST	SPOP	0.9245	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1031:1035	APSST	SPOP	0.9833	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1633:1637	APSST	SPOP	0.9841	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1656:1660	APSST	SPOP	0.8455	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	2880:2884	APSST	SPOP	0.9592	More...
Q8N183	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2	DEG_SPOP_SBC_1	146:150	APSST	SPOP	0.9957	More...
Q8NC01	C-type lectin domain family 1 member A	DEG_SPOP_SBC_1	42:46	APSST	SPOP	0.6529	More...
Q8NCD3	Holliday junction recognition protein	DEG_SPOP_SBC_1	658:662	APSST	SPOP	0.994	More...
Q96AY4	Tetratricopeptide repeat protein 28	DEG_SPOP_SBC_1	2199:2203	APSST	SPOP	0.9683	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	82:86	APSST	SPOP	0.9637	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2382:2386	APSST	SPOP	0.9772	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1137:1141	APSST	SPOP	0.855	More...
Q9P2K3	REST corepressor 3	DEG_SPOP_SBC_1	397:401	APSST	SPOP	0.8981	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	950:954	APSST	SPOP	0.9976	More...
O75956	Cyclin-dependent kinase 2-associated protein 2	DEG_SPOP_SBC_1	9:13	APSST	SPOP	0.9992	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	458:462	APSST	SPOP	0.708	More...
Q9HCE3	Zinc finger protein 532	DEG_SPOP_SBC_1	730:734	APSST	SPOP	0.9471	More...
A6NHS7	MANSC domain-containing protein 4	DEG_SPOP_SBC_1	173:177	APSST	SPOP	0.9451	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	334:338	APSST	SPOP	0.9671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSST

Degron related mutations and impact score

Drug responses associated with AGRN mutations

All proteins holding degron of APSST