DegronMD - A6NHS7(MANSC4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F223S	TCGA-AA-3984	COAD	TCGA	ISPFFE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.0833
p.F223S	DO9002	COAD	ICGC	ISPFFE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.0833
p.E172D	TCGA-AA-3984	COAD	TCGA	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.3056
p.E172D	DO9002	COAD	ICGC	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.3056
p.D181Y	TCGA-E6-A1LX	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.2222
p.D181Y	DO41020	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.2222
p.S244Y	TCGA-EO-A3AV	UCEC	TCGA	ISPFFE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.1389
p.S244Y	DO52412	UCEC	ICGC	ISPFFE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.1389
p.K230T	TCGA-F5-6814	READ	TCGA	ISPFFE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.2778
p.K230T	DO36556	READ	ICGC	ISPFFE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.2778
p.T163M	DO228483	BRCA	ICGC	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.T163M	DO229010	COCA	ICGC	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.T163M	DO228947	LICA	ICGC	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.T163M	DO230541	LUSC	ICGC	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.T178M	DO233634	GACA	ICGC	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.3056
p.T241K	DO228952	LICA	ICGC	ISPFFE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.2222
p.D228Y	DO36556	READ	ICGC	ISPFFE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.2222
p.D240H	DO231467	THCA	ICGC	ISPFFE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.25
p.T186R	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0833
p.T186R	ACH-000837	Lung Cancer	CCLE	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0833
p.T186R	NCI-H322M	lung	COSMIC	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0833
p.I224T	SIDM00272	Breast Carcinoma	GDSC	ISPFFE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.1111
p.I224T	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	ISPFFE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.1111
p.M167I	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1667
p.M167I	ACH-000121	Lung Cancer	CCLE	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1667
p.M167I	NCI-H2405	lung	COSMIC	APSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MANSC4

UniProt ID: A6NHS7

Entrez ID: 100287284

Protein name: MANSC domain-containing protein 4

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MANSC4 in