DegronMD

Uniprot ID: A6NHS7

Source protein: MANSC domain-containing protein 4

Source gene: MANSC4

Class: LIG_APCC_ABBA_1

Location: 232:237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9974

ASA_SCORE: 73.7667

COIL: 0.787

CONS_SCORE: 0.8586

DSS_SCORE: 0.4535

HELIX: 0.0352

FCONS_SCORE: 1.1287

RIG_SCORE: 0.7586

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F223S	TCGA-AA-3984	COAD	TCGA	ISPFFE	LIG_APCC_ABBA_1	0.0833
p.F223S	DO9002	COAD	ICGC	ISPFFE	LIG_APCC_ABBA_1	0.0833
p.S244Y	TCGA-EO-A3AV	UCEC	TCGA	ISPFFE	LIG_APCC_ABBA_1	0.1389
p.S244Y	DO52412	UCEC	ICGC	ISPFFE	LIG_APCC_ABBA_1	0.1389
p.K230T	TCGA-F5-6814	READ	TCGA	ISPFFE	LIG_APCC_ABBA_1	0.2778
p.K230T	DO36556	READ	ICGC	ISPFFE	LIG_APCC_ABBA_1	0.2778
p.T241K	DO228952	LICA	ICGC	ISPFFE	LIG_APCC_ABBA_1	0.2222
p.D228Y	DO36556	READ	ICGC	ISPFFE	LIG_APCC_ABBA_1	0.2222
p.D240H	DO231467	THCA	ICGC	ISPFFE	LIG_APCC_ABBA_1	0.25
p.I224T	SIDM00272	Breast Carcinoma	GDSC	ISPFFE	LIG_APCC_ABBA_1	0.1111
p.I224T	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	ISPFFE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NHS7	MANSC domain-containing protein 4	LIG_APCC_ABBA_1	232:237	ISPFFE	APC,CDC20,FZR1	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons