DegronMD - Q8NCD3(HJURP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q317H	TCGA-05-4396	LUAD	TCGA	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.25
p.R147K	TCGA-77-6844	LUSC	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.6126
p.R147K	DO26818	LUSC	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.6126
p.T178S	TCGA-86-A4JF	LUAD	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation altering degron motif	0.8227
p.R176C	TCGA-AJ-A3BG	UCEC	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation altering degron motif	0.719
p.E329Q	TCGA-AX-A2IO	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.1944
p.E329Q	DO40800	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.1944
p.P186L	TCGA-B5-A1MX	UCEC	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.2222
p.G333V	TCGA-B6-A0IJ	BRCA	TCGA	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0833
p.G333V	DO2813	BRCA	ICGC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0833
p.A171T	TCGA-B7-5816	STAD	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.2222
p.E165G	TCGA-BH-A1FH	BRCA	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.0556
p.E165G	TCGA-BH-A1FH	BRCA	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.0556
p.E165G	DO3946	BRCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.0556
p.E165G	DO3946	BRCA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.0556
p.K149I	TCGA-CJ-4920	KIRC	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.642
p.K149I	DO18681	KIRC	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.642
p.P191H	TCGA-EB-A24D	SKCM	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.0833
p.P141L	TCGA-EE-A2GO	SKCM	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1667
p.P141L	DO37823	SKCM	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1667
p.K143T	TCGA-EO-A22X	UCEC	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation substituting flanking lysine	0.3333
p.P326S	TCGA-F4-6703	COAD	TCGA	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.2778
p.P191L	TCGA-FR-A726	SKCM	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.0833
p.S649I	TCGA-HV-AA8V	PAAD	TCGA	APSST	DEG_SPOP_SBC_1	658:662	Mutation blocking phosphorylation signal	0.5278
p.E145Q	TCGA-VS-A958	CESC	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2778
p.E145Q	DO51639	CESC	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2778
p.V137M	DO225072	BRCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.0556
p.V137M	DO227701	BRCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.0556
p.E165Q	DO229357	BTCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.0556
p.E165Q	DO229357	BTCA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.0556
p.R318T	DO230316	COCA	ICGC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.2778
p.R315C	DO227973	COCA	ICGC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.1944
p.S327Y	DO222762	COCA	ICGC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.25
p.Y150C	DO222769	COCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.5976
p.R145G	DO229010	COCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2778
p.R145G	DO229013	COCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2778
p.R145G	DO229005	COCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2778
p.R145G	DO230659	LAML	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2778
p.R145G	DO231140	LAML	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.2778
p.K143R	DO222299	GACA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation substituting flanking lysine	0.3333
p.R173G	DO220479	KICH	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.2778
p.A172D	DO228948	LICA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.25
p.A171D	DO228985	LICA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.2222
p.P166T	DO229031	LICA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.0833
p.V325M	DO23866	LUAD	ICGC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.3056
p.L333F	DO219173	LUSC	ICGC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0833
p.P151L	DO52666	MALY	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation altering degron motif	0.7582
p.A190V	DO220882	MELA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.1111
p.P326L	DO220899	MELA	ICGC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.2778
p.P137L	DO48665	SKCM	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.0556
p.D651G	DO51776	STAD	ICGC	APSST	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1389
p.K146E	DO48009	STAD	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.3056
p.A658V	DO229253	THCA	ICGC	APSST	DEG_SPOP_SBC_1	658:662	Mutation altering degron motif	0.5825
p.V654I	DO42713	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	658:662	Mutation blocking phosphorylation signal	0.6667
p.G160D	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1944
p.G160D	ACH-000056	Lymphoma	CCLE	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1944
p.G160D	DOHH-2	haematopoietic and lymphoid tissue	COSMIC	RRKYLTQVD	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.1944
p.S320F	SIDM00007	Other Solid Cancers	GDSC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.6871
p.S320F	ACH-001550	Skin Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.6871
p.S320F	MCC13	skin	COSMIC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.6871
p.V188M	SIDM01101	Neuroblastoma	GDSC	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.1667
p.V188M	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.1667
p.V188M	SIDM01138	Pancreatic Carcinoma	GDSC	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.1667
p.G333E	SIDM00256	Neuroblastoma	GDSC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.0833
p.R315G	SIDM01686	Chronic Myelogenous Leukemia	GDSC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.1944
p.R315G	ACH-000462	Leukemia	CCLE	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.1944
p.P179R	ACH-001685	Lymphoma	CCLE	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation altering degron motif	0.7512
p.V325L	ESS-1	endometrium	COSMIC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.3056
p.V329L	EMC-BAC-1	lung	COSMIC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation rewiring degron network	0.1944
p.H184L	NCI-H1568	lung	COSMIC	VRVTPLPS	DEG_SCF_FBW7_1	175:182	Mutation rewiring degron network	0.2778
p.R320M	KM12	large intestine	COSMIC	SKENF	DEG_APCC_KENBOX_2	320:324	Mutation altering degron motif	0.8632

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HJURP

UniProt ID: Q8NCD3

Entrez ID: 55355

Protein name: Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HJURP in