DegronMD

Uniprot ID: Q8NCD3

Source protein: Holliday junction recognition protein

Source gene: HJURP

Class: DEG_APCC_KENBOX_2

Location: 320:324

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9053

ASA_SCORE: 104.08

COIL: 0.8572

CONS_SCORE: 0.3958

DSS_SCORE: 0.4765

HELIX: 0.098

FCONS_SCORE: 0.7939

RIG_SCORE: 0.6839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q317H	TCGA-05-4396	LUAD	TCGA	SKENF	DEG_APCC_KENBOX_2	0.25
p.E329Q	TCGA-AX-A2IO	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	0.1944
p.E329Q	DO40800	UCEC	ICGC	SKENF	DEG_APCC_KENBOX_2	0.1944
p.G333V	TCGA-B6-A0IJ	BRCA	TCGA	SKENF	DEG_APCC_KENBOX_2	0.0833
p.G333V	DO2813	BRCA	ICGC	SKENF	DEG_APCC_KENBOX_2	0.0833
p.P326S	TCGA-F4-6703	COAD	TCGA	SKENF	DEG_APCC_KENBOX_2	0.2778
p.R318T	DO230316	COCA	ICGC	SKENF	DEG_APCC_KENBOX_2	0.2778
p.R315C	DO227973	COCA	ICGC	SKENF	DEG_APCC_KENBOX_2	0.1944
p.S327Y	DO222762	COCA	ICGC	SKENF	DEG_APCC_KENBOX_2	0.25
p.V325M	DO23866	LUAD	ICGC	SKENF	DEG_APCC_KENBOX_2	0.3056
p.L333F	DO219173	LUSC	ICGC	SKENF	DEG_APCC_KENBOX_2	0.0833
p.P326L	DO220899	MELA	ICGC	SKENF	DEG_APCC_KENBOX_2	0.2778
p.S320F	SIDM00007	Other Solid Cancers	GDSC	SKENF	DEG_APCC_KENBOX_2	0.6871
p.S320F	ACH-001550	Skin Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	0.6871
p.S320F	MCC13	skin	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.6871
p.G333E	SIDM00256	Neuroblastoma	GDSC	SKENF	DEG_APCC_KENBOX_2	0.0833
p.R315G	SIDM01686	Chronic Myelogenous Leukemia	GDSC	SKENF	DEG_APCC_KENBOX_2	0.1944
p.R315G	ACH-000462	Leukemia	CCLE	SKENF	DEG_APCC_KENBOX_2	0.1944
p.V325L	ESS-1	endometrium	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.3056
p.V329L	EMC-BAC-1	lung	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.1944
p.R320M	KM12	large_intestine	COSMIC	SKENF	DEG_APCC_KENBOX_2	0.8632

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75330	Hyaluronan mediated motility receptor	DEG_APCC_KENBOX_2	695:699	SKENF	APC,CDC20,FZR1	0.9622	More...
O95425	Supervillin	DEG_APCC_KENBOX_2	1414:1418	SKENF	APC,CDC20,FZR1	0.9572	More...
Q8NCD3	Holliday junction recognition protein	DEG_APCC_KENBOX_2	320:324	SKENF	APC,CDC20,FZR1	0.9053	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_APCC_KENBOX_2	465:469	SKENF	APC,CDC20,FZR1	0.9549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons