DegronMD - O75330(HMMR)

HMMR

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A716S	TCGA-38-4632	LUAD	TCGA	LKTPLKE	DEG_SCF_FBW7_2	701:707	Mutation rewiring degron network	0.0833
p.F686C	TCGA-B5-A1MR	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	695:699	Mutation rewiring degron network	0.0833
p.K707E	TCGA-EE-A2MN	SKCM	TCGA	LKTPLKE	DEG_SCF_FBW7_2	701:707	Mutation altering degron motif	0.7022
p.G709S	TCGA-FR-A726	SKCM	TCGA	SKENF	DEG_APCC_KENBOX_2	695:699	Mutation rewiring degron network	0.0556
p.G709S	TCGA-FR-A726	SKCM	TCGA	LKTPLKE	DEG_SCF_FBW7_2	701:707	Mutation rewiring degron network	0.2778
p.A685S	DO228939	LICA	ICGC	SKENF	DEG_APCC_KENBOX_2	695:699	Mutation rewiring degron network	0.0556
p.A715S	DO23858	LUAD	ICGC	LKTPLKE	DEG_SCF_FBW7_2	701:707	Mutation rewiring degron network	0.1111
p.K691E	DO222438	MELA	ICGC	SKENF	DEG_APCC_KENBOX_2	695:699	Mutation rewiring degron network	0.2222
p.K691E	DO222438	MELA	ICGC	LKTPLKE	DEG_SCF_FBW7_2	701:707	Mutation rewiring degron network	0.0556
p.K691E	DO37423	SKCM	ICGC	SKENF	DEG_APCC_KENBOX_2	695:699	Mutation rewiring degron network	0.2222
p.K691E	DO37423	SKCM	ICGC	LKTPLKE	DEG_SCF_FBW7_2	701:707	Mutation rewiring degron network	0.0556
p.G693S	DO48665	SKCM	ICGC	SKENF	DEG_APCC_KENBOX_2	695:699	Mutation rewiring degron network	0.2778
p.G693S	DO48665	SKCM	ICGC	LKTPLKE	DEG_SCF_FBW7_2	701:707	Mutation rewiring degron network	0.1111
p.H692Y	ACH-001041	Skin Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	695:699	Mutation rewiring degron network	0.25
p.H692Y	ACH-001041	Skin Cancer	CCLE	LKTPLKE	DEG_SCF_FBW7_2	701:707	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc