DegronMD

Uniprot ID: O75330

Source protein: Hyaluronan mediated motility receptor

Source gene: HMMR

Class: DEG_APCC_KENBOX_2

Location: 695:699

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9622

ASA_SCORE: 102.88

COIL: 0.5364

CONS_SCORE: 0.5666

DSS_SCORE: 0.4776

HELIX: 0.436

FCONS_SCORE: 1.0006

RIG_SCORE: 0.7182

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F686C	TCGA-B5-A1MR	UCEC	TCGA	SKENF	DEG_APCC_KENBOX_2	0.0833
p.G709S	TCGA-FR-A726	SKCM	TCGA	SKENF	DEG_APCC_KENBOX_2	0.0556
p.A685S	DO228939	LICA	ICGC	SKENF	DEG_APCC_KENBOX_2	0.0556
p.K691E	DO222438	MELA	ICGC	SKENF	DEG_APCC_KENBOX_2	0.2222
p.K691E	DO37423	SKCM	ICGC	SKENF	DEG_APCC_KENBOX_2	0.2222
p.G693S	DO48665	SKCM	ICGC	SKENF	DEG_APCC_KENBOX_2	0.2778
p.H692Y	ACH-001041	Skin Cancer	CCLE	SKENF	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75330	Hyaluronan mediated motility receptor	DEG_APCC_KENBOX_2	695:699	SKENF	APC,CDC20,FZR1	0.9622	More...
O95425	Supervillin	DEG_APCC_KENBOX_2	1414:1418	SKENF	APC,CDC20,FZR1	0.9572	More...
Q8NCD3	Holliday junction recognition protein	DEG_APCC_KENBOX_2	320:324	SKENF	APC,CDC20,FZR1	0.9053	More...
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_APCC_KENBOX_2	465:469	SKENF	APC,CDC20,FZR1	0.9549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons