DegronMD

Uniprot ID: O75330

Source protein: Hyaluronan mediated motility receptor

Source gene: HMMR

Class: DEG_SCF_FBW7_2

Location: 701:707

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 102.4

COIL: 0.7856

CONS_SCORE: 0.4746

DSS_SCORE: 0.3969

HELIX: 0.1759

FCONS_SCORE: 1.0178

RIG_SCORE: 0.749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A716S	TCGA-38-4632	LUAD	TCGA	LKTPLKE	DEG_SCF_FBW7_2	0.0833
p.K707E	TCGA-EE-A2MN	SKCM	TCGA	LKTPLKE	DEG_SCF_FBW7_2	0.7022
p.G709S	TCGA-FR-A726	SKCM	TCGA	LKTPLKE	DEG_SCF_FBW7_2	0.2778
p.A715S	DO23858	LUAD	ICGC	LKTPLKE	DEG_SCF_FBW7_2	0.1111
p.K691E	DO222438	MELA	ICGC	LKTPLKE	DEG_SCF_FBW7_2	0.0556
p.K691E	DO37423	SKCM	ICGC	LKTPLKE	DEG_SCF_FBW7_2	0.0556
p.G693S	DO48665	SKCM	ICGC	LKTPLKE	DEG_SCF_FBW7_2	0.1111
p.H692Y	ACH-001041	Skin Cancer	CCLE	LKTPLKE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75330	Hyaluronan mediated motility receptor	DEG_SCF_FBW7_2	701:707	LKTPLKE	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons