DegronMD

Uniprot ID: Q8NCD3

Source protein: Holliday junction recognition protein

Source gene: HJURP

Class: DEG_SCF_FBW7_1

Location: 175:182

E3 ligase: FBXW7

DEGRON score: 0.88

ASA_SCORE: 66.55

COIL: 0.6474

CONS_SCORE: 0.592

DSS_SCORE: 0.4217

HELIX: 0.0388

FCONS_SCORE: 0.9401

RIG_SCORE: 0.7644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T178S	TCGA-86-A4JF	LUAD	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	0.8227
p.R176C	TCGA-AJ-A3BG	UCEC	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	0.719
p.P186L	TCGA-B5-A1MX	UCEC	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	0.2222
p.A171T	TCGA-B7-5816	STAD	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	0.2222
p.E165G	TCGA-BH-A1FH	BRCA	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	0.0556
p.E165G	DO3946	BRCA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	0.0556
p.P191H	TCGA-EB-A24D	SKCM	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	0.0833
p.P191L	TCGA-FR-A726	SKCM	TCGA	VRVTPLPS	DEG_SCF_FBW7_1	0.0833
p.E165Q	DO229357	BTCA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	0.0556
p.R173G	DO220479	KICH	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	0.2778
p.A172D	DO228948	LICA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	0.25
p.A171D	DO228985	LICA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	0.2222
p.P166T	DO229031	LICA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	0.0833
p.A190V	DO220882	MELA	ICGC	VRVTPLPS	DEG_SCF_FBW7_1	0.1111
p.V188M	SIDM01101	Neuroblastoma	GDSC	VRVTPLPS	DEG_SCF_FBW7_1	0.1667
p.V188M	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	VRVTPLPS	DEG_SCF_FBW7_1	0.1667
p.V188M	SIDM01138	Pancreatic Carcinoma	GDSC	VRVTPLPS	DEG_SCF_FBW7_1	0.1667
p.P179R	ACH-001685	Lymphoma	CCLE	VRVTPLPS	DEG_SCF_FBW7_1	0.7512
p.H184L	NCI-H1568	lung	COSMIC	VRVTPLPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCD3	Holliday junction recognition protein	DEG_SCF_FBW7_1	175:182	VRVTPLPS	FBXW7	0.88	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons