DegronMD

Uniprot ID: Q8NCD3

Source protein: Holliday junction recognition protein

Source gene: HJURP

Class: DEG_APCC_DBOX_1

Location: 147:155

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5749

ASA_SCORE: 75.7889

COIL: 0.3917

CONS_SCORE: 0.9856

DSS_SCORE: 0.1496

HELIX: 0.1769

FCONS_SCORE: 1.3908

RIG_SCORE: 0.8895

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R147K	TCGA-77-6844	LUSC	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	0.6126
p.R147K	DO26818	LUSC	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.6126
p.E165G	TCGA-BH-A1FH	BRCA	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	0.0556
p.E165G	DO3946	BRCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.0556
p.K149I	TCGA-CJ-4920	KIRC	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	0.642
p.K149I	DO18681	KIRC	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.642
p.P141L	TCGA-EE-A2GO	SKCM	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	0.1667
p.P141L	DO37823	SKCM	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.1667
p.K143T	TCGA-EO-A22X	UCEC	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	0.3333
p.E145Q	TCGA-VS-A958	CESC	TCGA	RRKYLTQVD	DEG_APCC_DBOX_1	0.2778
p.E145Q	DO51639	CESC	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.2778
p.V137M	DO225072	BRCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.0556
p.V137M	DO227701	BRCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.0556
p.E165Q	DO229357	BTCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.0556
p.Y150C	DO222769	COCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.5976
p.R145G	DO229010	COCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.2778
p.R145G	DO229013	COCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.2778
p.R145G	DO229005	COCA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.2778
p.R145G	DO230659	LAML	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.2778
p.R145G	DO231140	LAML	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.2778
p.K143R	DO222299	GACA	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.3333
p.P151L	DO52666	MALY	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.7582
p.P137L	DO48665	SKCM	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.0556
p.K146E	DO48009	STAD	ICGC	RRKYLTQVD	DEG_APCC_DBOX_1	0.3056
p.G160D	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRKYLTQVD	DEG_APCC_DBOX_1	0.1944
p.G160D	ACH-000056	Lymphoma	CCLE	RRKYLTQVD	DEG_APCC_DBOX_1	0.1944
p.G160D	DOHH-2	haematopoietic_and_lymphoid_tissue	COSMIC	RRKYLTQVD	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCD3	Holliday junction recognition protein	DEG_APCC_DBOX_1	147:155	RRKYLTQVD	APC,CDC20,FZR1	0.5749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRKYLTQVD

Degron related mutations and impact score

Drug responses associated with HJURP mutations

All proteins holding degron of RRKYLTQVD