DegronMD - P35637(FUS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q319H	TCGA-AX-A2HD	UCEC	TCGA	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation rewiring degron network	0.25
p.Q319H	DO42608	UCEC	ICGC	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation rewiring degron network	0.25
p.S108N	TCGA-BS-A0TE	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	105:109	Mutation altering degron motif	0.7069
p.T313A	DO228377	LICA	ICGC	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation rewiring degron network	0.0833
p.A104S	DO229022	LICA	ICGC	APSST	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.3056
p.G100V	DO229025	LICA	ICGC	APSST	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.1944
p.I321F	DO23122	LINC	ICGC	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation rewiring degron network	0.3056
p.K315R	DO228851	MALY	ICGC	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation substituting flanking lysine	0.25
p.G101D	DO232224	PBCA	ICGC	APSST	DEG_SPOP_SBC_1	105:109	Mutation rewiring degron network	0.2222
p.S107N	DO43506	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	105:109	Mutation altering degron motif	0.7069
p.D327H	SIDM01097	Other Solid Cancers	GDSC	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation altering degron motif	0.7688
p.D327H	ACH-001193	Bone Cancer	CCLE	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation altering degron motif	0.7688
p.D327H	SK-PN-DW	bone	COSMIC	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation altering degron motif	0.7688
p.K312Q	SIDM00877	Breast Carcinoma	GDSC	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation blocking ubiquitination signal	0.5
p.K312Q	ACH-000196	Breast Cancer	CCLE	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation blocking ubiquitination signal	0.5
p.K312Q	HCC1599	breast	COSMIC	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation blocking ubiquitination signal	0.5
p.P106L	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	105:109	Mutation altering degron motif	0.6471
p.P106L	ACH-000855	Esophageal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	105:109	Mutation altering degron motif	0.6471
p.P106L	KYSE-150	oesophagus	COSMIC	APSST	DEG_SPOP_SBC_1	105:109	Mutation altering degron motif	0.6471
p.K313Q	HCC1599	breast	COSMIC	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation rewiring degron network	0.0833
p.D326H	SK-PN-DW	bone	COSMIC	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation altering degron motif	0.7688
p.P105L	KYSE-150	oesophagus	COSMIC	APSST	DEG_SPOP_SBC_1	105:109	Mutation altering degron motif	0.7582
p.D328H	SK-PN-DW	bone	COSMIC	INLYTD	LIG_APCC_ABBA_1	322:327	Mutation rewiring degron network	0.3056

Kaplan plot for FUS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FUS

UniProt ID: P35637

Entrez ID: 2521

Protein name: RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FUS in