DegronMD

Uniprot ID: P35637

Source protein: RNA-binding protein FUS

Source gene: FUS

Class: LIG_APCC_ABBA_1

Location: 322:327

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6502

ASA_SCORE: 19.5

COIL: 0.1348

CONS_SCORE: 0.611

DSS_SCORE: 0.4563

HELIX: 0.0302

FCONS_SCORE: 1.0155

RIG_SCORE: 0.845

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q319H	TCGA-AX-A2HD	UCEC	TCGA	INLYTD	LIG_APCC_ABBA_1	0.25
p.Q319H	DO42608	UCEC	ICGC	INLYTD	LIG_APCC_ABBA_1	0.25
p.T313A	DO228377	LICA	ICGC	INLYTD	LIG_APCC_ABBA_1	0.0833
p.I321F	DO23122	LINC	ICGC	INLYTD	LIG_APCC_ABBA_1	0.3056
p.K315R	DO228851	MALY	ICGC	INLYTD	LIG_APCC_ABBA_1	0.25
p.D327H	SIDM01097	Other Solid Cancers	GDSC	INLYTD	LIG_APCC_ABBA_1	0.7688
p.D327H	ACH-001193	Bone Cancer	CCLE	INLYTD	LIG_APCC_ABBA_1	0.7688
p.D327H	SK-PN-DW	bone	COSMIC	INLYTD	LIG_APCC_ABBA_1	0.7688
p.K312Q	SIDM00877	Breast Carcinoma	GDSC	INLYTD	LIG_APCC_ABBA_1	0.5
p.K312Q	ACH-000196	Breast Cancer	CCLE	INLYTD	LIG_APCC_ABBA_1	0.5
p.K312Q	HCC1599	breast	COSMIC	INLYTD	LIG_APCC_ABBA_1	0.5
p.K313Q	HCC1599	breast	COSMIC	INLYTD	LIG_APCC_ABBA_1	0.0833
p.D326H	SK-PN-DW	bone	COSMIC	INLYTD	LIG_APCC_ABBA_1	0.7688
p.D328H	SK-PN-DW	bone	COSMIC	INLYTD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35637	RNA-binding protein FUS	LIG_APCC_ABBA_1	322:327	INLYTD	APC,CDC20,FZR1	0.6502	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons