DegronMD - Q8NC01(CLEC1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A51T	TCGA-06-0192	GBM	TCGA	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1944
p.A51T	DO13420	GBM	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1944
p.H32Q	TCGA-5P-A9K3	KIRP	TCGA	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0556
p.H32Q	DO223948	KIRP	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0556
p.R37C	TCGA-AP-A056	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1944
p.R37C	TCGA-FI-A2D5	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1944
p.R37C	DO41331	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1944
p.R37C	DO43971	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1944
p.P43L	TCGA-FW-A3R5	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	42:46	Mutation altering degron motif	0.6471
p.P43L	DO37406	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation altering degron motif	0.6471
p.P35L	TCGA-GN-A266	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1389
p.P35L	DO37432	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1389
p.Q55E	DO219064	BLCA	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0833
p.Q55E	ACH-000828	Breast Cancer	CCLE	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0833
p.Q55E	ZR-75-30	breast	COSMIC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0833
p.N55S	DO222884	COCA	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0833
p.W49C	DO228224	LICA	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.25
p.P49Q	DO228948	LICA	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.25
p.S54C	DO49715	LIHC	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1111
p.P43H	DO50780	LIRI	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation altering degron motif	0.6583
p.T48A	DO218922	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.2778
p.Y43F	DO24890	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation altering degron motif	0.7528
p.D54G	DO228810	PBCA	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1111
p.D54G	DO219945	SARC	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1111
p.Y42F	DO36342	PRAD	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation altering degron motif	0.7528
p.M56V	DO47849	STAD	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.0556
p.D51N	DO41644	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1944
p.V50A	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.2222
p.V50A	ACH-000395	Lung Cancer	CCLE	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.2222
p.V50A	NCI-H520	lung	COSMIC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.2222
p.L52P	SIDM01133	Other Solid Cancers	GDSC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1667
p.L52P	ACH-002177	Lung Cancer	CCLE	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1667
p.L52P	NCI-H835	lung	COSMIC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1667
p.R37H	SIDM00534	Colorectal Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1944
p.R37H	ACH-000986	Colon/Colorectal Cancer	CCLE	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1944
p.R37H	HT-115	large intestine	COSMIC	APSST	DEG_SPOP_SBC_1	42:46	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLEC1A

UniProt ID: Q8NC01

Entrez ID: 51267

Protein name: C-type lectin domain family 1 member A (C-type lectin-like receptor 1) (CLEC-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLEC1A in