DegronMD - Q9HCE3(ZNF532)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V65I	TCGA-A5-A0G2	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1111
p.V65I	DO41235	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1111
p.V63I	TCGA-AP-A0LM	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.V63I	TCGA-HF-A5NB	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.V63I	DO50127	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.V63I	DO43306	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.V63I	SIDM00216	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.V63I	ACH-000989	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.V63I	SNU-175	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.A397V	TCGA-AX-A05Y	UCEC	TCGA	DSGKKPS	DEG_SCF_TRCP1_1	387:393	Mutation rewiring degron network	0.2222
p.A397V	DO42897	UCEC	ICGC	DSGKKPS	DEG_SCF_TRCP1_1	387:393	Mutation rewiring degron network	0.2222
p.R379M	TCGA-EE-A181	SKCM	TCGA	DSGKKPS	DEG_SCF_TRCP1_1	387:393	Mutation rewiring degron network	0.1111
p.R379M	DO37444	SKCM	ICGC	DSGKKPS	DEG_SCF_TRCP1_1	387:393	Mutation rewiring degron network	0.1111
p.P738T	TCGA-G7-6795	KIRP	TCGA	APSST	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.2222
p.P738T	DO20851	KIRP	ICGC	APSST	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.2222
p.P392S	DO225152	BRCA	ICGC	DSGKKPS	DEG_SCF_TRCP1_1	387:393	Mutation altering degron motif	0.5641
p.G389V	DO50668	ORCA	ICGC	DSGKKPS	DEG_SCF_TRCP1_1	387:393	Mutation altering degron motif	0.7532
p.S733G	DO229272	THCA	ICGC	APSST	DEG_SPOP_SBC_1	730:734	Mutation altering degron motif	0.6993
p.L381F	SIDM01307	Colorectal Carcinoma	GDSC	DSGKKPS	DEG_SCF_TRCP1_1	387:393	Mutation rewiring degron network	0.1667
p.A739V	SIDM00437	Acute Myeloid Leukemia	GDSC	APSST	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.1944
p.A739V	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSST	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.1944
p.A739V	SIDM01145	Gastric Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.1944
p.A739V	SIDM00170	Head and Neck Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.1944
p.A739V	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	APSST	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.1944
p.A739V	SLVL	haematopoietic and lymphoid tissue	COSMIC	APSST	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.1944
p.A739V	NCI-SNU-16	stomach	COSMIC	APSST	DEG_SPOP_SBC_1	730:734	Mutation rewiring degron network	0.1944
p.T734I	SIDM00321	Ovarian Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	730:734	Mutation altering degron motif	0.7078
p.T734I	SIDM01434	Hepatocellular Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	730:734	Mutation altering degron motif	0.7078
p.T734I	TYK-nu	ovary	COSMIC	APSST	DEG_SPOP_SBC_1	730:734	Mutation altering degron motif	0.7078
p.G47R	SIDM00217	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.G47R	ACH-000999	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.G47R	SNU-1040	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.A53T	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.7139
p.A53T	ACH-000925	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF532

UniProt ID: Q9HCE3

Entrez ID: 55205

Protein name: Zinc finger protein 532

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF532 in