DegronMD

Uniprot ID: Q9HCE3

Source protein: Zinc finger protein 532

Source gene: ZNF532

Class: DEG_SCF_TRCP1_1

Location: 387:393

E3 ligase: BTRC

DEGRON score: 0.8266

ASA_SCORE: 83.3429

COIL: 0.81

CONS_SCORE: 0.4163

DSS_SCORE: 0.4978

HELIX: 0.169

FCONS_SCORE: 0.8794

RIG_SCORE: 0.6773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A397V	TCGA-AX-A05Y	UCEC	TCGA	DSGKKPS	DEG_SCF_TRCP1_1	0.2222
p.A397V	DO42897	UCEC	ICGC	DSGKKPS	DEG_SCF_TRCP1_1	0.2222
p.R379M	TCGA-EE-A181	SKCM	TCGA	DSGKKPS	DEG_SCF_TRCP1_1	0.1111
p.R379M	DO37444	SKCM	ICGC	DSGKKPS	DEG_SCF_TRCP1_1	0.1111
p.P392S	DO225152	BRCA	ICGC	DSGKKPS	DEG_SCF_TRCP1_1	0.5641
p.G389V	DO50668	ORCA	ICGC	DSGKKPS	DEG_SCF_TRCP1_1	0.7532
p.L381F	SIDM01307	Colorectal Carcinoma	GDSC	DSGKKPS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCE3	Zinc finger protein 532	DEG_SCF_TRCP1_1	387:393	DSGKKPS	BTRC	0.8266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons