DegronMD

Uniprot ID: Q9UBL0

Source protein: cAMP-regulated phosphoprotein 21

Source gene: ARPP21

Class: DEG_SPOP_SBC_1

Location: 458:462

E3 ligase: SPOP

DEGRON score: 0.708

ASA_SCORE: 59.2

COIL: 0.8838

CONS_SCORE: 0.4567

DSS_SCORE: 0.2998

HELIX: 0.0558

FCONS_SCORE: 0.9517

RIG_SCORE: 0.7441

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D460E	TCGA-D7-6817	STAD	TCGA	APSST	DEG_SPOP_SBC_1	0.6758
p.D460E	DO38352	STAD	ICGC	APSST	DEG_SPOP_SBC_1	0.6758
p.L448H	TCGA-DD-AADF	LIHC	TCGA	APSST	DEG_SPOP_SBC_1	0.0556
p.L448H	DO52232	LIHC	ICGC	APSST	DEG_SPOP_SBC_1	0.0556
p.T470P	TCGA-EB-A4XL	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	0.1111
p.T470P	DO47401	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	0.1111
p.G461E	TCGA-EE-A3AE	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	0.7199
p.G461E	DO37802	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	0.7199
p.N467S	TCGA-EO-A22T	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	0.1944
p.N467S	DO42320	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	0.1944
p.Y466C	TCGA-EO-A3AV	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	0.2222
p.Y466C	DO52412	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	0.2222
p.P450L	TCGA-ER-A42L	SKCM	TCGA	APSST	DEG_SPOP_SBC_1	0.1111
p.P450L	DO223910	SKCM	ICGC	APSST	DEG_SPOP_SBC_1	0.1111
p.P450Q	TCGA-SJ-A6ZI	UCEC	TCGA	APSST	DEG_SPOP_SBC_1	0.1111
p.P450Q	DO219784	UCEC	ICGC	APSST	DEG_SPOP_SBC_1	0.1111
p.V457L	DO228948	LICA	ICGC	APSST	DEG_SPOP_SBC_1	0.3056
p.S471I	DO229019	LICA	ICGC	APSST	DEG_SPOP_SBC_1	0.0833
p.M459I	DO23858	LUAD	ICGC	APSST	DEG_SPOP_SBC_1	0.7618
p.P455S	DO222644	MELA	ICGC	APSST	DEG_SPOP_SBC_1	0.25
p.A464V	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	0.2778
p.A464V	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSST	DEG_SPOP_SBC_1	0.2778
p.A464V	NCI-H2135	lung	COSMIC	APSST	DEG_SPOP_SBC_1	0.2778
p.I453L	ACH-000219	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	0.1944
p.I453L	ACH-002001	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	0.1944
p.I453L	ACH-002002	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	0.1944
p.I453L	ACH-002003	Skin Cancer	CCLE	APSST	DEG_SPOP_SBC_1	0.1944
p.I453L	A375	skin	COSMIC	APSST	DEG_SPOP_SBC_1	0.1944
p.T462S	ACH-000775	Lung Cancer	CCLE	APSST	DEG_SPOP_SBC_1	0.6005
p.T462S	NCI-H727	lung	COSMIC	APSST	DEG_SPOP_SBC_1	0.6005
p.Y448C	ACH-000932	Gastric Cancer	CCLE	APSST	DEG_SPOP_SBC_1	0.0556
p.Y448C	NCI-SNU-1	stomach	COSMIC	APSST	DEG_SPOP_SBC_1	0.0556
p.R456Q	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	APSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00468	Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment	DEG_SPOP_SBC_1	1007:1011	APSST	SPOP	0.8779	More...
O14745	Na	DEG_SPOP_SBC_1	310:314	APSST	SPOP	0.9989	More...
O95071	E3 ubiquitin-protein ligase UBR5	DEG_SPOP_SBC_1	1730:1734	APSST	SPOP	0.9784	More...
O95677	Eyes absent homolog 4	DEG_SPOP_SBC_1	246:250	APSST	SPOP	0.7114	More...
P35637	RNA-binding protein FUS	DEG_SPOP_SBC_1	105:109	APSST	SPOP	0.9597	More...
P46379	Large proline-rich protein BAG6	DEG_SPOP_SBC_1	414:418	APSST	SPOP	0.8466	More...
P48378	DNA-binding protein RFX2	DEG_SPOP_SBC_1	101:105	APSST	SPOP	0.9989	More...
P51617	Interleukin-1 receptor-associated kinase 1	DEG_SPOP_SBC_1	175:179	APSST	SPOP	0.9726	More...
P80723	Brain acid soluble protein 1	DEG_SPOP_SBC_1	192:196	APSST	SPOP	0.9979	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1508:1512	APSST	SPOP	0.9994	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1881:1885	APSST	SPOP	0.9979	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	3235:3239	APSST	SPOP	0.9704	More...
Q14244	Ensconsin	DEG_SPOP_SBC_1	456:460	APSST	SPOP	0.9245	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1031:1035	APSST	SPOP	0.9833	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1633:1637	APSST	SPOP	0.9841	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1656:1660	APSST	SPOP	0.8455	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	2880:2884	APSST	SPOP	0.9592	More...
Q8N183	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2	DEG_SPOP_SBC_1	146:150	APSST	SPOP	0.9957	More...
Q8NC01	C-type lectin domain family 1 member A	DEG_SPOP_SBC_1	42:46	APSST	SPOP	0.6529	More...
Q8NCD3	Holliday junction recognition protein	DEG_SPOP_SBC_1	658:662	APSST	SPOP	0.994	More...
Q96AY4	Tetratricopeptide repeat protein 28	DEG_SPOP_SBC_1	2199:2203	APSST	SPOP	0.9683	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	82:86	APSST	SPOP	0.9637	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	2382:2386	APSST	SPOP	0.9772	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_SPOP_SBC_1	1137:1141	APSST	SPOP	0.855	More...
Q9P2K3	REST corepressor 3	DEG_SPOP_SBC_1	397:401	APSST	SPOP	0.8981	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	950:954	APSST	SPOP	0.9976	More...
O75956	Cyclin-dependent kinase 2-associated protein 2	DEG_SPOP_SBC_1	9:13	APSST	SPOP	0.9992	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	458:462	APSST	SPOP	0.708	More...
Q9HCE3	Zinc finger protein 532	DEG_SPOP_SBC_1	730:734	APSST	SPOP	0.9471	More...
A6NHS7	MANSC domain-containing protein 4	DEG_SPOP_SBC_1	173:177	APSST	SPOP	0.9451	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	334:338	APSST	SPOP	0.9671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSST

Degron related mutations and impact score

Drug responses associated with ARPP21 mutations

All proteins holding degron of APSST