Degron: APSST
85.96
0.9498
0.2609
0.4825
0.028
0.9171
0.607
Degron related mutations and impact score
| Mutation | Sample | Cancer | Dataset | Degron | Degron class | Impact score |
| p.P449L | TCGA-2F-A9KT | BLCA | TCGA | APSST | DEG_SPOP_SBC_1 | 0.1389 |
| p.A450V | TCGA-AP-A0LP | UCEC | TCGA | APSST | DEG_SPOP_SBC_1 | 0.1667 |
| p.A450V | DO43146 | UCEC | ICGC | APSST | DEG_SPOP_SBC_1 | 0.1667 |
| p.A464T | TCGA-BG-A222 | UCEC | TCGA | APSST | DEG_SPOP_SBC_1 | 0.2222 |
| p.A464T | DO42977 | UCEC | ICGC | APSST | DEG_SPOP_SBC_1 | 0.2222 |
| p.A447T | TCGA-W3-A828 | SKCM | TCGA | APSST | DEG_SPOP_SBC_1 | 0.0833 |
| p.A447T | DO51273 | SKCM | ICGC | APSST | DEG_SPOP_SBC_1 | 0.0833 |
| p.S457L | DO222990 | BTCA | ICGC | APSST | DEG_SPOP_SBC_1 | 0.7667 |
| p.S457L | DO229028 | LICA | ICGC | APSST | DEG_SPOP_SBC_1 | 0.7667 |
| p.S465L | SIDM01034 | B-Lymphoblastic Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01020 | Plasma Cell Myeloma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01265 | Plasma Cell Myeloma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00425 | Ovarian Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00615 | Hepatocellular Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00611 | Kidney Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00614 | Hepatocellular Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00144 | Non-Small Cell Lung Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01197 | Colorectal Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00565 | Oral Cavity Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00411 | Pancreatic Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00393 | Gastric Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00781 | Colorectal Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01069 | Non-Small Cell Lung Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00553 | Acute Myeloid Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01005 | Acute Myeloid Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00465 | Ovarian Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00374 | B-Cell Non-Hodgkin's Lymphoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00492 | Glioblastoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01032 | Esophageal Squamous Cell Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00092 | Ovarian Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00351 | Oral Cavity Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01079 | Melanoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00562 | Breast Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00278 | Esophageal Squamous Cell Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01045 | Endometrial Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00489 | Oral Cavity Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00290 | Gastric Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00609 | Kidney Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00347 | Esophageal Squamous Cell Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00368 | Small Cell Lung Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00306 | Non-Small Cell Lung Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00361 | Non-Small Cell Lung Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00316 | Glioblastoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00412 | B-Cell Non-Hodgkin's Lymphoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01608 | Endometrial Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01569 | Hepatocellular Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01617 | Endometrial Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01470 | Acute Myeloid Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01460 | Glioma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01336 | Glioblastoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00166 | Other Solid Cancers | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01573 | Plasma Cell Myeloma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00780 | Colorectal Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM00784 | Glioma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01658 | Unknown | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01685 | B-Lymphoblastic Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01753 | Gastric Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.S465L | SIDM01574 | Plasma Cell Myeloma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.1944 |
| p.M459T | SIDM01034 | B-Lymphoblastic Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00425 | Ovarian Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01020 | Plasma Cell Myeloma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01265 | Plasma Cell Myeloma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00615 | Hepatocellular Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00611 | Kidney Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00614 | Hepatocellular Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01197 | Colorectal Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00565 | Oral Cavity Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00411 | Pancreatic Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00393 | Gastric Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00781 | Colorectal Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01069 | Non-Small Cell Lung Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00553 | Acute Myeloid Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01005 | Acute Myeloid Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00465 | Ovarian Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00374 | B-Cell Non-Hodgkin's Lymphoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00492 | Glioblastoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01032 | Esophageal Squamous Cell Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00092 | Ovarian Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00351 | Oral Cavity Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01079 | Melanoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00562 | Breast Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00278 | Esophageal Squamous Cell Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01045 | Endometrial Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00489 | Oral Cavity Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00290 | Gastric Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00609 | Kidney Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00347 | Esophageal Squamous Cell Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00368 | Small Cell Lung Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00306 | Non-Small Cell Lung Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00361 | Non-Small Cell Lung Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00316 | Glioblastoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00412 | B-Cell Non-Hodgkin's Lymphoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00785 | Acute Myeloid Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01608 | Endometrial Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01569 | Hepatocellular Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01617 | Endometrial Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01470 | Acute Myeloid Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01460 | Glioma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01444 | Glioblastoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01336 | Glioblastoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00166 | Other Solid Cancers | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01573 | Plasma Cell Myeloma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00780 | Colorectal Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM00784 | Glioma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01658 | Unknown | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01685 | B-Lymphoblastic Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01753 | Gastric Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.M459T | SIDM01574 | Plasma Cell Myeloma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.7423 |
| p.A464G | SIDM00723 | Non-Small Cell Lung Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.2222 |
| p.M459L | SIDM00629 | Breast Carcinoma | GDSC | APSST | DEG_SPOP_SBC_1 | 0.711 |
| p.T446I | SIDM00951 | T-Lymphoblastic Leukemia | GDSC | APSST | DEG_SPOP_SBC_1 | 0.0556 |
| p.T446I | CTV-1 | haematopoietic_and_lymphoid_tissue | COSMIC | APSST | DEG_SPOP_SBC_1 | 0.0556 |
| p.K454N | HCC2998 | large_intestine | COSMIC | APSST | DEG_SPOP_SBC_1 | 0.2778 |
| p.K462E | CW-2 | large_intestine | COSMIC | APSST | DEG_SPOP_SBC_1 | 0.2778 |
| p.E455K | PANC-08-13 | pancreas | COSMIC | APSST | DEG_SPOP_SBC_1 | 0.3056 |
| p.R463G | SCC90 | upper_aerodigestive_tract | COSMIC | APSST | DEG_SPOP_SBC_1 | 0.25 |
| p.D460Y | RS4-11 | haematopoietic_and_lymphoid_tissue | COSMIC | APSST | DEG_SPOP_SBC_1 | 0.7325 |
| p.L470P | TE-4 | oesophagus | COSMIC | APSST | DEG_SPOP_SBC_1 | 0.0556 |
| p.A469D | SW626 | ovary | COSMIC | APSST | DEG_SPOP_SBC_1 | 0.0833 |
Drug responses associated with MAP7 mutations
| Sample | Cancer | Mutation (In Degron?) | Dataset | Drug | IC50 |
All proteins holding degron of APSST
| Uniprot ID | Source protein | Degron class | Location | Hit | E3 ligase | Degron score | Detail |
| O00468 | Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment | DEG_SPOP_SBC_1 | 1007:1011 | APSST | SPOP | 0.8779 | More... |
| O14745 | Na | DEG_SPOP_SBC_1 | 310:314 | APSST | SPOP | 0.9989 | More... |
| O95071 | E3 ubiquitin-protein ligase UBR5 | DEG_SPOP_SBC_1 | 1730:1734 | APSST | SPOP | 0.9784 | More... |
| O95677 | Eyes absent homolog 4 | DEG_SPOP_SBC_1 | 246:250 | APSST | SPOP | 0.7114 | More... |
| P35637 | RNA-binding protein FUS | DEG_SPOP_SBC_1 | 105:109 | APSST | SPOP | 0.9597 | More... |
| P46379 | Large proline-rich protein BAG6 | DEG_SPOP_SBC_1 | 414:418 | APSST | SPOP | 0.8466 | More... |
| P48378 | DNA-binding protein RFX2 | DEG_SPOP_SBC_1 | 101:105 | APSST | SPOP | 0.9989 | More... |
| P51617 | Interleukin-1 receptor-associated kinase 1 | DEG_SPOP_SBC_1 | 175:179 | APSST | SPOP | 0.9726 | More... |
| P80723 | Brain acid soluble protein 1 | DEG_SPOP_SBC_1 | 192:196 | APSST | SPOP | 0.9979 | More... |
| P98088 | Mucin-5AC | DEG_SPOP_SBC_1 | 1508:1512 | APSST | SPOP | 0.9994 | More... |
| P98088 | Mucin-5AC | DEG_SPOP_SBC_1 | 1881:1885 | APSST | SPOP | 0.9979 | More... |
| Q03164 | Histone-lysine N-methyltransferase 2A | DEG_SPOP_SBC_1 | 3235:3239 | APSST | SPOP | 0.9704 | More... |
| Q14244 | Ensconsin | DEG_SPOP_SBC_1 | 456:460 | APSST | SPOP | 0.9245 | More... |
| Q6P4R8 | Nuclear factor related to kappa-B-binding protein | DEG_SPOP_SBC_1 | 1031:1035 | APSST | SPOP | 0.9833 | More... |
| Q6ZRS2 | Helicase SRCAP | DEG_SPOP_SBC_1 | 1633:1637 | APSST | SPOP | 0.9841 | More... |
| Q6ZRS2 | Helicase SRCAP | DEG_SPOP_SBC_1 | 1656:1660 | APSST | SPOP | 0.8455 | More... |
| Q6ZRS2 | Helicase SRCAP | DEG_SPOP_SBC_1 | 2880:2884 | APSST | SPOP | 0.9592 | More... |
| Q8N183 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 | DEG_SPOP_SBC_1 | 146:150 | APSST | SPOP | 0.9957 | More... |
| Q8NC01 | C-type lectin domain family 1 member A | DEG_SPOP_SBC_1 | 42:46 | APSST | SPOP | 0.6529 | More... |
| Q8NCD3 | Holliday junction recognition protein | DEG_SPOP_SBC_1 | 658:662 | APSST | SPOP | 0.994 | More... |
| Q96AY4 | Tetratricopeptide repeat protein 28 | DEG_SPOP_SBC_1 | 2199:2203 | APSST | SPOP | 0.9683 | More... |
| Q96JG9 | Zinc finger protein 469 | DEG_SPOP_SBC_1 | 82:86 | APSST | SPOP | 0.9637 | More... |
| Q96JG9 | Zinc finger protein 469 | DEG_SPOP_SBC_1 | 2382:2386 | APSST | SPOP | 0.9772 | More... |
| Q9NR99 | Matrix-remodeling-associated protein 5 | DEG_SPOP_SBC_1 | 1137:1141 | APSST | SPOP | 0.855 | More... |
| Q9P2K3 | REST corepressor 3 | DEG_SPOP_SBC_1 | 397:401 | APSST | SPOP | 0.8981 | More... |
| O14513 | Nck-associated protein 5 | DEG_SPOP_SBC_1 | 950:954 | APSST | SPOP | 0.9976 | More... |
| O75956 | Cyclin-dependent kinase 2-associated protein 2 | DEG_SPOP_SBC_1 | 9:13 | APSST | SPOP | 0.9992 | More... |
| Q9UBL0 | cAMP-regulated phosphoprotein 21 | DEG_SPOP_SBC_1 | 458:462 | APSST | SPOP | 0.708 | More... |
| Q9HCE3 | Zinc finger protein 532 | DEG_SPOP_SBC_1 | 730:734 | APSST | SPOP | 0.9471 | More... |
| A6NHS7 | MANSC domain-containing protein 4 | DEG_SPOP_SBC_1 | 173:177 | APSST | SPOP | 0.9451 | More... |
| Q8N1P7 | Beta/gamma crystallin domain-containing protein 2 | DEG_SPOP_SBC_1 | 334:338 | APSST | SPOP | 0.9671 | More... |