DegronMD - Q9P2K3(RCOR3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P481L	TCGA-77-A5GF	LUSC	TCGA	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.1944
p.P481L	DO50101	LUSC	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.1944
p.P484L	TCGA-A6-2686	COAD	TCGA	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.1111
p.P484L	DO7828	COAD	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.1111
p.T459P	TCGA-A6-6780	COAD	TCGA	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.0833
p.T459P	DO10244	COAD	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.0833
p.R392W	TCGA-AA-3984	COAD	TCGA	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1667
p.R392W	TCGA-AA-3984	COAD	TCGA	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.R392W	DO9002	COAD	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1667
p.R392W	DO9002	COAD	ICGC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.E396Q	TCGA-BT-A2LA	BLCA	TCGA	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.2778
p.E396Q	TCGA-BT-A2LA	BLCA	TCGA	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.3056
p.E396Q	DO561	BLCA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.2778
p.E396Q	DO561	BLCA	ICGC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.3056
p.L469Q	TCGA-DD-A4NO	LIHC	TCGA	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation altering degron motif	0.7765
p.L469Q	DO45013	LIHC	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation altering degron motif	0.7765
p.T463A	TCGA-RC-A7SB	LIHC	TCGA	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.1944
p.T463A	DO219581	LIHC	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.1944
p.D414N	DO52646	BOCA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.0833
p.G404S	DO10639	COAD	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.6993
p.R391C	DO222762	COCA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1389
p.R391C	DO222762	COCA	ICGC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1667
p.R391C	DO233864	GACA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1389
p.R391C	DO233864	GACA	ICGC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1667
p.S392T	DO50306	ESAD	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1667
p.S392T	DO50306	ESAD	ICGC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.E397G	DO228552	LICA	ICGC	APSST	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7199
p.Q471H	DO228952	LICA	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation altering degron motif	0.7582
p.G404C	DO228985	LICA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.76
p.G404C	DO47112	RECA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.76
p.G404C	Daudi	haematopoietic and lymphoid tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.76
p.V387L	DO229022	LICA	ICGC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0556
p.G413C	DO229035	LICA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1111
p.C402R	DO47112	RECA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.8301
p.C402R	Daudi	haematopoietic and lymphoid tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.8301
p.C402R	DND-41	haematopoietic and lymphoid tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation altering degron motif	0.8301
p.N394D	SIDM01095	Rhabdomyosarcoma	GDSC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.2222
p.N394D	SIDM01095	Rhabdomyosarcoma	GDSC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.25
p.N394D	ACH-000833	Sarcoma	CCLE	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.2222
p.N394D	ACH-000833	Sarcoma	CCLE	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.25
p.N394D	SJRH30	soft tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.2222
p.N394D	SJRH30	soft tissue	COSMIC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.25
p.G413A	SIDM00845	Burkitt's Lymphoma	GDSC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1111
p.G413A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1111
p.G413A	SIDM01519	Head and Neck Carcinoma	GDSC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1111
p.G413A	ACH-000786	Lymphoma	CCLE	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1111
p.G413A	ACH-000992	Head and Neck Cancer	CCLE	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1111
p.G413A	DND-41	haematopoietic and lymphoid tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1111
p.G413A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1111
p.A464V	SIDM00845	Burkitt's Lymphoma	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	SIDM01169	Ovarian Carcinoma	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	SIDM00035	Thyroid Gland Carcinoma	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	SIDM00461	Acute Myeloid Leukemia	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	SIDM01519	Head and Neck Carcinoma	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	ACH-000037	Sarcoma	CCLE	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	ACH-000786	Lymphoma	CCLE	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	ACH-000885	Ovarian Cancer	CCLE	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	ACH-000992	Head and Neck Cancer	CCLE	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	S-117	soft tissue	COSMIC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	Daudi	haematopoietic and lymphoid tissue	COSMIC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.A464V	TOV-21G	ovary	COSMIC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.2222
p.T468I	SIDM00516	Melanoma	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation altering degron motif	0.7078
p.T468I	ACH-002166	Skin Cancer	CCLE	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation altering degron motif	0.7078
p.T468I	MZ7-mel	skin	COSMIC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation altering degron motif	0.7078
p.S411F	SIDM00721	Small Cell Lung Carcinoma	GDSC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1667
p.S411F	SIDM00721	Small Cell Lung Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0556
p.S411F	ACH-002171	Lung Cancer	CCLE	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1667
p.S411F	ACH-002171	Lung Cancer	CCLE	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0556
p.S411F	NCI-H250	lung	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1667
p.S411F	NCI-H250	lung	COSMIC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0556
p.A406V	TOV-21G	ovary	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.3056
p.A406V	TOV-21G	ovary	COSMIC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.A406V	Daudi	haematopoietic and lymphoid tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.3056
p.A406V	Daudi	haematopoietic and lymphoid tissue	COSMIC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.A406V	S-117	soft tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.3056
p.A406V	S-117	soft tissue	COSMIC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.P395L	KM12	large intestine	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.25
p.P395L	KM12	large intestine	COSMIC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2778
p.T410I	MZ7-mel	skin	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.1944
p.T410I	MZ7-mel	skin	COSMIC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0833
p.A409T	Daudi	haematopoietic and lymphoid tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.2222
p.A409T	Daudi	haematopoietic and lymphoid tissue	COSMIC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1111
p.A408T	Daudi	haematopoietic and lymphoid tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	398:405	Mutation rewiring degron network	0.25
p.A408T	Daudi	haematopoietic and lymphoid tissue	COSMIC	APSST	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1389
p.I484T	JHOS-2	ovary	COSMIC	PRPVLSTVG	DEG_APCC_DBOX_1	468:476	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RCOR3

UniProt ID: Q9P2K3

Entrez ID: 55758

Protein name: REST corepressor 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RCOR3 in